Senior Scientist

Randstad USA; St. Louis (MO); On-site; USD 55,000 - 65,000; Full time

Job summary

Randstad USA is seeking a Senior Scientist for the Analytical R&D department at their St. Louis facility.

The role focuses on designing, validating, and implementing advanced LC‑MS assays to quantify proteins within complex biological mixtures, spanning from early development to manufacturing. Ideal candidates hold a BS in Chemistry and show hands‑on mastery of high‑resolution and triple quadrupole LC‑MS platforms, plus strong sample prep skills for large biomolecules and a collaborative,

Qualifications

• Bachelor of Science in Chemistry or related science field.
• Hands-on proficiency with high‑resolution and triple quadrupole LC‑MS platforms.
• Experience in sample preparation for large biomolecules (digestion, enrichment, depletion, labeling).
• Strong collaborative and independent problem‑solving with good scientific communication.

Responsibilities

• Lead design, development, and validation of LC‑MS assays for quantifying proteins in complex mixtures.
• Characterize large biomolecules including monoclonal antibodies, multispecifics, and ADCs.
• Prepare complex samples using digestion, enrichment, depletion, and labeling techniques.
• Collaborate with product development, manufacturing, and project leaders to advance programs.
• Maintain, calibrate, and troubleshoot LC‑MS instrumentation.

Skills

LC-MS systems

Triple quadrupole MS

Sample preparation

Collaboration

Education

Bachelor of Science in Chemistry

Tools

High-resolution LC-MS

Triple quadrupole LC-MS

Job description

job summary:

Join a premier global life sciences innovator at their cutting‑edge R&D facility in vibrant St. Louis, Missouri. As a Senior Scientist in the Analytical R&D Department, you will deliver critical analytical support to drive next‑generation therapeutics from early development through manufacturing.

location: St. Louis MO

job type: Contract

salary: $40-$47 an hour

work hours: 9:00 AM – 5:00 PM

education: Bachelors Degree

responsibilities:

• Lead the design, development, and validation of advanced LC‑MS assays for the quantitation of proteins in complex biological mixtures.
• Perform high‑level structural characterization of large biomolecules, including monoclonal antibodies, multispecifics, and antibody‑drug conjugates (ADCs).
• Prepare complex samples using enzymatic and chemical techniques such as digestion, enrichment, depletion, and labeling.
• Partner cross‑functionally with product development, manufacturing teams, and multidisciplinary project leaders to advance pipeline programs.
• Maintain, calibrate, and troubleshoot high‑resolution and triple quadrupole LC‑MS instrumentation.

qualifications:

• Bachelor of Science in Chemistry or a related scientific discipline.
• Demonstrated hands‑on proficiency with advanced high‑resolution and triple quadrupole LC‑MS platforms.
• Proven expertise in sample preparation methodologies for large biomolecules (digestion, enrichment, depletion, and labeling).
• Strong collaborative and independent problem‑solving capabilities with excellent scientific communication skills.

#LI-AM1

Equal Opportunity Employer: Race, Color, Religion, Sex, Sexual Orientation, Gender Identity, National Origin, Age, Genetic Information, Disability, Protected Veteran Status, or any other legally protected group status.

Pay offered to a successful candidate will be based on several factors including the candidate's education, work experience, work location, specific job duties, certifications, etc. In addition, Randstad offers a comprehensive benefits package, including: medical, prescription, dental, vision, AD&D, and life insurance offerings, short‑term disability, and a 401K plan (all benefits are based on eligibility).

This posting is open for thirty (30) days.