Senior Analytical Scientist

BuzzClan; St. Louis (MO); On-site; USD 90,000 - 140,000; Full time

Job summary

BuzzClan is seeking a Senior Analytical Scientist to join our Analytical R&D team in St. Louis. You will lead LC-MS assay development for protein quantitation and perform high-level characterization of large biomolecules, including monoclonal antibodies and ADCs.

Ideal candidates have a BS in Chemistry with hands-on LC-MS/MS experience and a track record in Cross-functional collaboration. PhD in Analytical Chemistry is a plus. Local candidates preferred.

Qualifications

• BS in Chemistry, Analytical Chemistry, or related field.
• Hands-on experience with high-resolution and triple quadrupole LC-MS platforms.
• Experience with enzymatic and chemical sample preparation for large biomolecules.
• Ability to work independently and collaborate with cross-functional teams.

Responsibilities

• Lead LC-MS assay development for protein quantitation.
• Perform advanced characterization of large biomolecules including monoclonal antibodies and ADCs.
• Collaborate with cross-functional teams to drive analytical initiatives.

Skills

LC-MS/MS

Protein quantitation

MRM/PRM

Independent work

Cross-functional collaboration

Education

PhD in Analytical Chemistry

BS in Chemistry/Analytical Chemistry

Tools

UNIFI

BioPharma Finder

Mascot

Scaffold

Thermo

Sciex

Waters

Agilent

MALDI-MS

ESI-MS

Job description

Schedule: Monday-Friday, 40 hours/week (flexible shifts)Lab Work: 80% laboratory-based

Experience: Strong hands-on Mass Spectrometry experience

Preference: Local candidates

Job Summary

Seeking a Senior Analytical Scientist to join the Analytical R&D team. The candidate will lead LC-MS assay development for protein quantitation and perform advanced characterization of large biomolecules, including monoclonal antibodies, multispecific antibodies, and antibody-drug conjugates (ADCs).

Required Qualifications

• BS in Chemistry, Analytical Chemistry, or related field.
• Hands-on experience with high-resolution and triple quadrupole LC-MS platforms.
• Experience with enzymatic and chemical sample preparation for large biomolecules.
• Ability to work independently and collaborate with cross-functional teams.

Preferred Qualifications

• PhD in Analytical Chemistry or related field.
• Protein and antibody quantitation using MRM/PRM mass spectrometry.
• Bottom-up, middle-up/down, and top-down protein LC-MS workflows.
• Experience with peptide mapping, disulfide mapping, PTM characterization and glycosylation profiling.
• Experience with intact mass analysis and free thiol analysis.
• Bioinformatics tools: UNIFI, BioPharma Finder, Mascot, Scaffold.
• Instrument experience: Thermo, Sciex, Waters, Agilent.
• Hands-on MALDI-MS and ESI-MS experience.

Look for candidates with:

• PhD in Analytical Chemistry, Biochemistry, Chemistry or related discipline.
• Strong LC-MS/MS and protein characterization experience.
• Hands-on experience with MRM/PRM and antibody quantitation.
• Biopharmaceutical or biologics analytical R&D background.
• Ability to independently develop and execute analytical methods.