Bioanalytical Scientist

Mindlance; Andover (MA); On-site; USD 60,000 - 90,000; Full time

Job summary

A leading biotech company is seeking a bioanalytical scientist to join their innovative mass spectrometry laboratory in Andover, MA. The candidate will develop quantitative assays for anti-drug antibodies in protein biotherapeutics while conducting bioanalytical procedures and maintaining laboratory instruments. A Bachelor's degree is required along with strong skills in protein biochemistry and mass spectrometry. The role offers the opportunity to contribute significantly to immunogenicity studies and participate in diverse phases of laboratory operations.

Qualifications

• Experience in applying protein quantitation workflows.
• Ability to run bioanalytical assays with minimal supervision.
• Proficiency in maintaining and troubleshooting mass spectrometry instruments.

Responsibilities

• Develop and execute bioanalytical assays for anti-drug antibodies.
• Perform sample preparation and data analysis/reporting.
• Maintain laboratory instruments and ensure proper operation.

Skills

Protein quantitation workflows

Liquid handling robotics

LC-MS/MS data analysis

Education

Bachelor's degree

Tools

Triple quadrupole mass spectrometry

Multi-dimensional nanoflow liquid chromatography

Job description

Job Description

Duration: 36+ month

Location: Andover, MA

A rare position is available for a bioanalytical scientist to join a state-of-the-art protein mass spectrometry laboratory in the Pharmacokinetics Dynamics and Metabolism department. The role will focus on the development of a novel type of sensitive quantitative assay to characterize and quantify the effect of anti‑drug antibodies against protein biotherapeutics in the context of unwanted immunogenicity. This position requires expertise in bioanalytical procedures including immunoanalytical workflows, solid background in protein biochemistry, and ideally expertise in triple quadrupole quantitative mass spectrometry. The candidate will participate in all phases of mass spectrometry laboratory operations including the development of sample preparation methods, assay execution, instrument maintenance and data analysis/reporting. We are looking for a scientist passionate about learning and quickly applying new skills to the project needs.

Qualifications

• Apply existing protein quantitation workflows using bead and column based immunoaffinity enrichment including the use of liquid handling robotics.
• Run bioanalytical assays under minimal supervision; initiative in method development is expected.
• Independent daily operation, calibration, maintenance, and troubleshooting of multi‑dimensional nanoflow liquid chromatography and nanospray triple quadrupole mass spectrometry instrumentation.
• Support analysis of quantitative LC‑MS/MS data using relevant bioinformatics and quantitation software.
• Minimum education experience required: Bachelors.

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