Scientist/Senior Scientist In Vitro Biology

Atalanta Therapeutics, Inc.; Boston (MA); On-site; USD 140,000 - 210,000; Full time

Job summary

Atalanta Therapeutics, Inc. is seeking an experienced molecular and cellular biologist to lead the InVitro Biology team and the high-throughput screening (HTS) effort.

The role centers on expanding screening capabilities to evaluate siRNA efficacy in mammalian cells and to support preclinical drug development for multiple targets. The candidate should have strong skills in microplate-based cell culture, automated liquid handling, and a background in neurobiology.

Qualifications

• Experience with cell-based assay development and assay validation.
• Experience in high-throughput screening and data analysis.

Responsibilities

• Implementing and optimizing high throughput automated processes for siRNA screening.
• Developing and standardizing cell-based assays and expression analyses.
• Analyzing data and statistics to evaluate assay performance.
• Leading and mentoring research associates in screening efforts.
• Collaborating with project teams to adapt assays to HTS formats and prioritize screens.
• Communicating designs, progress and results to teams through reports and presentations.

Skills

Cell-based assays

HTS automation

mRNA expression analysis

ELISA / multiplex assays

Assay development

Molecular biology

Stable cell lines

Statistical analysis

Neurodegenerative disease

Independent work

Education

PhD in neuroscience/biochemistry or related field

BS/MS with relevant experience

Job description

Atalanta is seeking an experienced, highlymotivated, and detail-oriented molecular and cellular biologist to join our InVitro Biology team and lead the high-throughput screening team. AsHTS team lead, this person will be responsible for the development andexpansion of our screening capabilities to evaluate siRNA efficacy in mammaliancells and will oversee the implementation of HTS to supportpreclinicaldrug development for multiple therapeutic targets.

Candidatemust be familiar with microplate-based cell culture and automated liquidhandling. A background in neurobiology and/or familiarity with neuronal cellassay development is a plus.

EssentialFunctions:

• Implementing and optimizing high throughputautomated processes to accelerate siRNA compound screening and evaluation incell-based assays.
• Developing and standardizing cell-basedassays, using skills in molecular cloning, stable cell line generation, cellculture and expression analysis to assess biological activity of potential siRNA therapeuticcandidates
• Application of data analysis tools to assessbiological activity and assay performance and for statistical analysis ofexperimental data
• Managing research associates in theperformance of screening assays, in a matrixed organization
• Interfacing with multiple project teams toadapt assays to high throughput formats, stage and prioritize screens,iteratively improve processes, and identify strong therapeutic lead compounds
• Communicating study designs, progress andresults through strong interpersonal interactions as well as slide presentationsand reports

Required Qualifications:

• Technical expertise in cell-based bioassays, high-throughputscreening automation, mRNA expression analysis and ELISA/multiplex assays.
• A strong background in assay development,optimization and validation.
• Expertise in molecular biology, includingcreation of stable cell lines for target evaluation
• A demonstrated ability to work with largeexperimental data sets including statistical analyses.
• Experience in neurodegenerative and neurologicaldisease research
• Ability to work and think independently andcontribute as a part of a highly matrixed team
• Self-motivation, ability to multi-task, capacityto handle multiple and changing priorities as well as fluctuations in theworkload
• Excellent organization skills and strongattention to detail
• Outstanding problem-solving skills, ability toindependently analyze and present data to scientific teams, excellentcommunication skills (oral and written)

Education

• Ph.D. inneuroscience, biochemistry, or a relevant biological science with an additional3+ years of relevant industry experience in assay development and highthroughput screening, or a B.S./M.S. with equivalent experience

Atalanta is committed to equalemployment opportunity and non-discrimination for all employees and qualifiedapplicants without regard to a person’s race, color, gender, age, religion,national origin, ancestry, disability, veteran status, genetic information,sexual orientation or any characteristic protected under applicable law.Atalanta will make reasonable accommodations for qualified individuals withknown disabilities, in accordance with applicable law.