Scientist - Metabolomics/Lipidomics

Oncology Voice Network LLC; Waltham, Northern (MA, KY); Hybrid; USD 110,000 - 160,000; Full time

Job summary

Oncology Voice Network LLC in Massachusetts seeks a Metabolomics/Lipidomics Scientist to lead LC/MS and LC/MS/MS analyses, performing targeted and non-targeted studies, and developing novel methods to support the platform. You will conceptualize experiments, analyze data, and report results with rigorous QA/QC.

The role requires a Ph.D. in analytical chemistry or biochemistry with 1+ years in metabolomics, hands-on MS/HPLC troubleshooting, and experience with sample prep techniques.

Qualifications

• Ph.D. in analytical chemistry or biochemistry required.
• 1+ years of experience in metabolomics/lipidomics.
• Experience with LC/MS / LC-MS/MS and method development.
• Strong troubleshooting of HPLC and MS instrumentation.
• Excellent communication and documentation skills.

Responsibilities

• Conceptualize, perform, analyze, and report experiments.
• Develop mass spectrometry-based assays for metabolites.
• Maintain analytical instrumentation and QA/QC.
• Develop SOPs and regulatory-compliant reports.
• Collaborate with external partners.

Skills

Analytical chemistry

Biochemistry

Metabolomics/lipidomics

Mass spectrometry expertise

HPLC proficiency

Communication skills

Team collaboration

Technical troubleshooting

Report writing

Education

Ph.D. in analytical chemistry or biochemistry

Tools

HPLC

MS

MS/MS

SPE

LLE

Job description

## Job DescriptionPOSITION SUMMARY: The Metabolomics/Lipidomics Scientist will have extensive experience in metabolite and/or small molecule analysis using LC/MS and LC/MS/MS platforms. The scientist will perform targeted and nontargeted bioanalysis and develop novel methods to support the platform. ESSENTIAL DUTIES AND RESPONSIBILITIES: - Responsible for the full spectrum of activities involved in metabolomics/lipidomics analysis as a member of the team including the following: - Conceptualize, perform, analyze and report experiments. - Perform mass spectrometry-based assays and studies focused on metabolite analysis of diverse samples from the biological matrices. - Laboratory analytical instrumentation routine maintenance. - Daily QA/QC, system suitability testing, method development and validated SOP implementation - Develop SOPs. - Manage external collaborations. - Other duties, as assigned. QUALIFICATIONS: - Ph.D. (with 1+ years of experience) in analytical chemistry, biochemistry, or a related field in the analysis of small molecules and metabolites by mass spectrometry. - Broad understanding of metabolomics/lipidomics applications and biochemistry in the areas of systems biology, neurodegeneration, obesity, cardiovascular disease, and cancer is a plus. - Proven ability to troubleshoot common instrumentation-related issues, specifically for HPLC and MS systems. - Experience with common sample preparation techniques, including solid phase extraction (SPE), liquid-liquid extraction and protein precipitation for biofluids, tissues and cells. - Deep understanding of core HPLC and MS concepts, including (but not limited to) principles of reversed-phase LC and HILIC, high-resolution/accurate mass strategies, structural elucidation by MS/MS, isotope dilution, isotopologue identification, multiple-charged ions. - Excellent communication and interpersonal skills combined with a proven track record of technical and organizational skills. - Must be able to work in a team-oriented environment and demonstrate attention to detail and record-keeping. Must demonstrate fully professional level requiring independent work in metabolomics research and development. - Knowledge of Microsoft Word, Excel, and PowerPoint required for preparation of reports to management. - Ability to prepare manuscripts for presentation, publication in scientific journals, and regulatory requirements is preferred.