Senior Scientist, Untargeted LC-MS Metabolomics & Lipidomics

Advanced Regenerative Manufacturing Institute (ARMl); Manchester (NH); On-site; USD 110,000 - 160,000; Full time

Benefits offered by this job

Biomek automation

Job summary

Advanced Regenerative Manufacturing Institute (ARMl) is seeking a highly motivated scientist for our Multi-Omics group to advance untargeted metabolomics and lipidomics in bioprocesses. The role involves developing pipelines, preparing samples for LC-MS, and analyzing data across groups to deliver actionable biological insights.

You will operate Thermo LC-MS systems, automate workflows, and collaborate with data science to push bioprocess understanding forward in human health applications.

Qualifications

• Hands-on experience with untargeted metabolomics and lipidomics across bioprocesses.
• Experience with LC-MS workflows, sample prep, and data interpretation.
• Proficient in automation and high-throughput workflows.

Responsibilities

• Develop an untargeted analyses pipeline for polar metabolites and lipids from bioreactor samples.
• Prepare samples for LC-MS and leverage automation to increase throughput.
• Operate and maintain Thermo LC-MS instruments (Vanquish UHPLC, Exploris 480, IQ-X).
• Analyze LC-MS data using Compound Discoverer, LipidSearch, MZmine; use Python/R for scripting.
• Collaborate across Multi-Omics, Process Development, and Data Science to derive insights.
• Coordinate with Operations and vendors for instrument maintenance and upgrades.
• Adhere to safety and quality guidelines and SOPs.

Skills

Untargeted metabolomics

Untargeted lipidomics

LC-MS operation

Sample handling automation

Python/R scripting

Education

MS in Chemistry/Biochemistry/Biotechnology

PhD with 2–5 years postgraduate experience

Tools

Compound Discoverer

LipidSearch

MZmine

Biomemk automation (Biomek)

Job description

Overview

The Advanced Regenerative Manufacturing Institute (ARMl)IBioFabUSA is a Member-based non-profit, member-driven, public-private partnership with a mission to advance the bioeconomy and transform the future of human health. ARMI provides technical and wrap-around commercialization services to companies seeking to advance technologies that will contribute to this impact.

The Impact That You Will Make

ARMI is seeking a highly motivated scientist to join our growing Multi-Omics group to develop and apply state-of-the-art methodologies to interrogate small molecule signatures within our bioprocesses. The successful candidate will spearhead efforts to characterize metabolomics and lipidomics profiles across processes in manufacturing cell-based therapy products, collaborating across groups for multi-omic analysis. The ideal candidate will have demonstrated expertise in untargeted metabolomics and/or lipidomics and extensive hands-on experience with sample handling automation, LC-MS instrumentation, and data analysis software platforms.

Your Role

• Develop an optimized pipeline for deep, untargeted analysis of polar metabolites and lipids from bioreactor cultured cells and conditioned media.
• Prepare bioreactor samples for liquid chromatography-mass spectrometry analysis, leveraging automation for improved throughput.
• Operate and maintain Thermo LC-MS instrumentation, including Vanquish UHPLC, Exploris 480, and IQ-X.
• Analyze LC-MS raw data with processing software including Compound Discoverer, LipidSearch, MZmine, and Python/R scripting.
• Collaborate closely within the Multi-Omics group and across Process Development and Data Science groups to discover and communicate biological insights that will deliver impact.
• Engage with Operations Support, service engineers, and vendors for instrument maintenance, optimization, and upgrades.
• Adhere to safety and quality guidelines and SOPs.

Your Skills and Experiences

• Degree in Chemistry, Biochemistry, Biotechnology or related area. MS with 5-10 years of experience or PhD with 2-5 years postgraduate experience.
• Significant hands-on experience across all stages of untargeted small molecule analyses: sample preparation, mass spectrometric analyses, and data processing and interpretation.
• Familiarity with lab automation and higher-throughput workflows. Experience with Biomek systems is a plus.
• Good communication skills, proactive attitude, and results-driven mindset.

Work Environment & Schedule Expectations

• Work in a laboratory environment with exposure to biological materials, chemical reagents, and analytical instrumentation.
• Ability to stand for extended periods and safely operate laboratory equipment.
• Occasional work outside of regular business hours, including evening, weekend, or overtime work may be required to support critical project timelines and business needs.
• Limited travel may be required for conferences, training, or client meetings.