Scientist - Metabolomics/Lipidomics

BPGbio, Inc.; Waltham (MA); On-site; USD 100,000 - 160,000; Full time

Job summary

BPGbio, Inc. in Waltham, MA seeks a Metabolomics/Lipidomics Scientist with extensive MS-based experience to lead targeted and non-targeted bioanalysis using LC/MS and LC/MS/MS platforms.

You will conceptualize experiments, develop novel methods, perform analyses on diverse biological samples, maintain instruments, and contribute to SOPs, QA/QC, and external collaborations, reporting results to management.

Qualifications

• Ph.D. in analytical chemistry, biochemistry, or a related field with MS experience.
• Broad understanding of metabolomics/lipidomics applications in disease contexts such as neurodegeneration, obesity, cardiovascular disease, and cancer.
• Proven ability to troubleshoot common instrumentation issues, specifically for HPLC and MS systems.
• Experience with sample preparation techniques including SPE, liquid-liquid extraction and protein precipitation for biofluids, tissues and cells.
• Deep understanding of core LC and MS concepts, including MS/MS, isotope dilution, isotopologue identification, and high-resolution mass strategies.
• Excellent communication and organizational skills with detail-focused record-keeping.
• Knowledge of MS Office (Word, Excel, PowerPoint) for reports.

Responsibilities

• Conceptualize, perform, analyze and report experiments.
• Perform mass spectrometry-based assays on diverse samples.
• Laboratory instrumentation maintenance and QA/QC.
• Develop SOPs and system suitability tests.
• Manage external collaborations.
• Other duties as assigned.

Skills

Mass spectrometry

LC-MS

Method development

SOP development

QA/QC

Scientific communication

Team collaboration

Education

Ph.D. in analytical chemistry or related field

Tools

HPLC

MS instrumentation

SPE

Job description

The Metabolomics/Lipidomics Scientist will have extensive experience in metabolite and/or small molecule analysis using LC/MS and LC/MS/MS platforms. The scientist will perform targeted and nontargeted bioanalysis and develop novel methods to support the platform.

ESSENTIAL DUTIES AND RESPONSIBILITIES:

• Responsible for the full spectrum of activities involved in metabolomics/lipidomics analysis as a member of the team including the following:
• Conceptualize, perform, analyze and report experiments.
• Perform mass spectrometry-based assays and studies focused on metabolite analysis of diverse samples from the biological matrices.
• Laboratory analytical instrumentation routine maintenance.
• Daily QA/QC, system suitability testing, method development and validated SOP implementation
• Develop SOPs.
• Manage external collaborations.
• Other duties, as assigned.

QUALIFICATIONS:

• Ph.D. (with 1+ years of experience) in analytical chemistry, biochemistry, or a related field in the analysis of small molecules and metabolites by mass spectrometry.
• Broad understanding of metabolomics/lipidomics applications and biochemistry in the areas of systems biology, neurodegeneration, obesity, cardiovascular disease, and cancer is a plus.
• Proven ability to troubleshoot common instrumentation-related issues, specifically for HPLC and MS systems.
• Experience with common sample preparation techniques, including solid phase extraction (SPE), liquid-liquid extraction and protein precipitation for biofluids, tissues and cells.
• Deep understanding of core HPLC and MS concepts, including (but not limited to) principles of reversed-phase LC and HILIC, high-resolution/accurate mass strategies, structural elucidation by MS/MS, isotope dilution, isotopologue identification, multiple-charged ions.
• Excellent communication and interpersonal skills combined with a proven track record of technical and organizational skills.
• Must be able to work in a team-oriented environment and demonstrate attention to detail and record-keeping. Must demonstrate fully professional level requiring independent work in metabolomics research and development.
• Knowledge of Microsoft Word, Excel, and PowerPoint required for preparation of reports to management.
• Ability to prepare manuscripts for presentation, publication in scientific journals, and regulatory requirements is preferred.