Senior Scientist- Metabolomics

Sirius Talent Group; New York (NY); On-site; USD 120,000 - 150,000; Full time

Job summary

Sirius Staffing in New York is seeking a Senior Scientist – Metabolomics to join a growing life sciences organization. This hands-on role focuses on LC-MS/MS, metabolomics, and lipidomics with small-molecule analysis, method development, and data interpretation.

You will develop and optimize analytical methods, analyze experiments, troubleshoot instrumentation, and support projects from development to results, mentoring junior scientists as needed.

Qualifications

• PhD with 2+ years post-graduate experience OR Master's with 5+ years experience.
• Hands-on LC-MS/MS and mass spectrometry instrumentation experience.
• Experience with metabolomics, lipidomics, metabolite analysis, or quantitative small-molecule analysis.

Responsibilities

• Develop, optimize, and validate LC-MS/MS methods for metabolomics, lipidomics, and small-molecule analysis.
• Prepare and analyze biological samples using techniques like protein precipitation, LLE, and SPE.
• Operate and troubleshoot LC and mass spectrometry systems, including triple quadrupole and high-resolution instruments.
• Analyze and interpret mass spectrometry data, including metabolite identification and quantification.
• Support instrument maintenance, validation, and troubleshooting.
• Prepare SOPs, validation docs, and technical reports.
• Collaborate with scientists and project teams to plan studies and communicate results.
• Provide mentorship to junior scientists as needed.

Skills

LC-MS/MS

Metabolomics

Lipidomics

Small-molecule analysis

Method development

Data analysis

Troubleshooting

Documentation

Education

PhD in Analytical Chemistry/ Biochemistry/ Chemistry/ Pharmaceutical Sciences (or related)

Master's degree with 5+ years of experience

Tools

SCIEX QTRAP 6500

Thermo Q Exactive

Triple quadrupole mass spectrometers

Job description

We are seeking a Senior Scientist – Metabolomics to join a growing life sciences organization in New York. This is a hands-on laboratory position for a scientist with strong experience in LC-MS/MS, metabolomics, lipidomics , or small-molecule analysis .

You will help develop and improve analytical methods, perform and analyze experiments, troubleshoot laboratory instrumentation, and support research projects from initial method development through final results . This is an excellent opportunity for an experienced analytical scientist who enjoys hands-on laboratory work, method development, and solving complex scientific problems

Responsibilities

• Develop, optimize, and validate LC-MS/MS methods for metabolomics, lipidomics , and small-molecule analysis.
• Prepare and analyze biological samples using techniques such as protein precipitation, liquid-liquid extraction (LLE), and solid-phase extraction (SPE).
• Operate and troubleshoot LC and mass spectrometry systems , including triple quadrupole and high-resolution mass spectrometers.
• Analyze and interpret mass spectrometry data, including metabolite identification and small-molecule quantification.
• Support instrument maintenance, validation, and troubleshooting.
• Prepare SOPs, validation documentation, and technical reports.
• Work with other scientists and project teams to plan studies, solve technical challenges, and communicate results.
• Provide technical guidance and mentorship to junior scientists as needed.

What We're Looking For

• PhD in Analytical Chemistry, Biochemistry, Chemistry, Pharmaceutical Sciences, or a related life sciences field with 2+ years of relevant post-graduate experience , OR a Master's degree with 5+ years of relevant experience .
• Hands‑on experience with LC‑MS/MS and mass spectrometry instrumentation .
• Experience with metabolomics, lipidomics , metabolite analysis, or quantitative small‑molecule analysis .
• Experience developing, optimizing, or validating analytical methods.
• Familiarity with mass spectrometry platforms such as SCIEX QTRAP 6500, Thermo Q Exactive , triple quadrupole systems, or comparable instrumentation .
• Experience preparing biological samples for LC-MS analysis.
• Working knowledge of LC separation techniques such as reversed‑phase chromatography and/or HILIC.
• Ability to troubleshoot experiments and instrumentation and independently interpret scientific data.
• Strong documentation, communication, and project‑management skills.

Experience with GLP environments, assay validation, SOP development, and regulated pharmaceutical or bioanalytical laboratory work is highly valued.

• Relocation assistance and visa sponsorship are available for qualified candidates.

Sirius Staffing is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, disability, veteran status, sexual orientation, gender identity, or any other status protected by applicable law