Scientist, LNP Discovery Biology

EMD Serono, Inc.; Billerica (MA); On-site; USD 82,000 - 123,000; Full time

Benefits offered by this job

Health insurance

Paid time off

Retirement contributions

Job summary

EMD Serono, Inc. is seeking a Scientist for LNP Discovery Biology to support the LNP biology platform through laboratory-based work and collaboration with cross-functional teams.

You will run in vitro and ex vivo assays and support in vivo studies to drive candidate selection, including human T cell and PBMC work, with a focus on CAR readouts and transfection efficiency. The role requires 5+ years in industry, 1+ year of mammalian cell culture and flow cytometry experience (or equivalent via

Qualifications

• Bachelor's or higher in Immunology, Biology, Molecular Biology or Life Sciences.
• 5+ years of industry experience.
• 1+ years of mammalian cell culture and flow cytometry experience.
• OR Master's with 3+ years experience and mammalian cell culture/flow cytometry, OR PhD with 6+ months experience.

Responsibilities

• Run in vitro and ex vivo assays for the LNP delivery platform, including primary human T cell and PBMC cultures, transfection efficiency, CAR expression, and functional readouts.
• Execute multicolor flow cytometry panels, acquire data, and perform analysis of CAR expression, reporter signal, target cell depletion, and T cell activation/engraftment.
• Process samples from in vivo studies and contribute to assembling datasets with pharmacology.
• Help optimize and troubleshoot assays and develop new ones under supervision.
• Analyze your data, prepare figures, and present results in group meetings.
• Maintain rigorous records in electronic lab notebook and ensure protocol adherence.
• Contribute to SOPs for the assays you run.

Skills

Mammalian cell culture

Flow cytometry

Education

Bachelor's degree in Life Sciences

Master's degree in Life Sciences

PhD in Life Sciences

Tools

Multicolor flow cytometry (6+ colors)

qPCR

ELISA

Western blot

Job description

Work Your Magic with us! Start your next chapter and join EMD Serono.

Ready to explore, break barriers, and discover more? We know you’ve got big plans – so do we! Our colleagues across the globe love innovating with science and technology to enrich people’s lives with our solutions in Healthcare, Life Science, and Electronics. Together, we dream big and are passionate about caring for our rich mix of people, customers, patients, and planet. That's why we are always looking for curious minds that see themselves imagining the unimaginable with us.

United As One for Patients, our purpose in Healthcare is to help create, improve and prolong lives. We develop medicines, intelligent devices and innovative technologies in therapeutic areas such as Oncology, Neurology and Fertility. Our teams work together across 6 continents with passion and relentless curiosity in order to help patients at every stage of life. Joining our Healthcare team is becoming part of a diverse, inclusive and flexible working culture, presenting great opportunities for personal development and career advancement across the globe.

This role does not offer sponsorship for work authorization. External applicants must be eligible to work in the US.

Your Role

The Scientist, LNP Discovery Biology position is a laboratory-based role supporting the LNP biology platform and targeted delivery programs. You will run the in vitro and ex vivo assays that generate the program's core data, and support in vivo studies, that drive candidate selection.

• Run in vitro and ex vivo assays supporting the targeted LNP delivery platform, including primary human T cell and PBMC cultures, transfection efficiency, CAR expression, and functional readouts.
• Execute multicolor flow cytometry panels, acquire data on the cytometer, and perform the analysis — CAR expression, reporter signal, target cell depletion, T cell activation and engraftment.
• Process samples from in vivo studies and contribute to assembling the resulting datasets, in collaboration with pharmacology group.
• Help optimize and troubleshoot assays, and contribute to developing new ones under the direction of senior colleagues.
• Analyze your own data, prepare clear figures, and present results in group meetings.
• Maintain rigorous records: electronic lab notebook, protocol adherence, reagent qualification, and sample and inventory tracking.
• Contribute to protocols and SOPs for the assays you run.

Who You Are

Minimum Qualifications:

• Bachelors Degree in Immunology, Biology, Molecular Biology or other Life Science discipline.
• 5+ years of industry experience.
• 1+ years of experience with mammalian cell culture and flow cytometry.

OR

• Master’s Degree in Immunology, Cell Biology, Molecular Biology other Life Science discipline.
• 3+ years of industry experience.
• 1+ years of experience with mammalian cell culture and flow cytometry.

OR

• PhD in Immunology, Cell Biology, Molecular Biology other Life Science discipline.
• 6+ months of experience with mammalian cell culture and flow cytometry.

Preferred Qualifications

• Familiarity with CAR biology or cell therapy readouts.
• Experience supporting rodent in vivo studies: blood collection, tissue harvest, and sample processing, with current or recent animal handling training.
• Experience with mRNA, LNP, or other nucleic acid delivery systems, including in vitro transfection.
• Experience with primary human immune cell work: PBMC isolation, T cell activation, and expansion.
• Multicolor flow cytometry experience (6+ colors), including panel setup and compensation.
• Experience with standard molecular and protein methods: qPCR, ELISA, Western blot, plate-based assays.
• Comfortable in a fast-moving, collaborative group where priorities can shift week to week.
• Ability to follow established protocols precisely and to document work clearly in an electronic lab notebook.
• Comfortable managing several experiments in parallel and meeting agreed timelines.
• Clear communication of methods and results, including presenting data in group meetings.

Pay Range for this position: $81,700-$122,500

Benefits

• Benefits offered by the Company include health insurance, paid time off (PTO), retirement contributions, and other perquisites.