Scientist, Preclinical Pharmacology - Therapeutic Area Expansion

EMD Serono, Inc.; Billerica (MA); On-site; USD 90,000 - 136,000; Full time

Benefits offered by this job

Health insurance

PTO

Retirement contributions

Perquisites

Job summary

EMD Serono, Inc. in Billerica, MA is seeking a Scientist II, Preclinical Pharmacology. The role reports to the Principal Scientist and leads independent in vivo pharmacology studies across immunology, neuroscience, and other areas.

You will contribute to translational PK/PD and biomarker strategies, executing disease-model work with high scientific independence. You will manage CRO collaborations and ensure study timelines, quality, and compliance with protocol standards, IACUC, AAALAC, and GLP

Qualifications

• PhD with 4+ years hands-on in vivo pharmacology experience required.
• Masters with 6+ years in vivo pharmacology experience acceptable.
• Bachelor’s with 8+ years in vivo pharmacology experience acceptable.

Responsibilities

• Establish, validate, and troubleshoot in vivo disease models to defined milestones.
• Generate target engagement and translational in vivo pharmacology data packages.
• Execute in vivo pharmacology studies across multiple disease models and routes of administration.
• Manage CRO partnerships and external study execution while maintaining timelines.
• Champion GLP, AAALAC, and IACUC compliance in the in vivo group.
• Contribute to translational PK/PD and biomarker data integration.

Skills

In vivo pharmacology

Education

PhD in Pharmacology

Masters in Life Sciences

Bachelor’s in Life Sciences

Job description

Work Your Magic with us! Start your next chapter and join EMD Serono.

Ready to explore, break barriers, and discover more? We know you’ve got big plans – so do we! Our colleagues across the globe love innovating with science and technology to enrich people’s lives with our solutions in Healthcare, Life Science, and Electronics. Together, we dream big and are passionate about caring for our rich mix of people, customers, patients, and planet. That's why we are always looking for curious minds that see themselves imagining the unimaginable with us.

United As One for Patients, our purpose in Healthcare is to help create, improve and prolong lives. We develop medicines, intelligent devices and innovative technologies in therapeutic areas such as Oncology, Neurology and Fertility. Our teams work together across 6 continents with passion and relentless curiosity in order to help patients at every stage of life. Joining our Healthcare team is becoming part of a diverse, inclusive and flexible working culture, presenting great opportunities for personal development and career advancement across the globe.

This role does not offer sponsorship for work authorization. External applicants must be eligible to work in the US.

Your Role

EMD Serono in Billerica, MA is hiring a Scientist II, Preclinical Pharmacology. This position reports to the Principal Scientist / Lab Head and is accountable for the independent scientific execution of in vivo pharmacology studies supporting programs across immunology, neuroscience, and other therapeutic areas. This role contributes to translational PK/PD and biomarker strategies, executes disease-model studies across multiple therapeutic areas, operating with a high degree of technical independence.

Responsibilities

Scientific & Pharmacology

• Establish, validate, optimize, and troubleshoot fit-for-purpose in vivo disease models — including acute and chronic disease-relevant models — to defined validation milestones and reproducibility criteria
• Build and apply disease models to evaluate efficacy across therapeutic areas, including immunology, neuroscience, fertility, rare diseases and other therapeutic areas under consideration
• Generate target engagement, pharmacodynamic response, and translational in vivo pharmacology packages of novel therapeutic approaches, delivering study-ready data packages on schedule and in compliance with protocol and quality standards

In Vivo Pharmacology

• Hands on execution of in vivo pharmacology studies across disease models — including dosing via IV, SC, IP, PO, ICV, and IT routes, blood and CSF sampling, tissue collection, and necropsy — delivering study-ready samples on schedule and in compliance with protocol and quality standards
• Perform and support surgical procedures relevant to broad set of pharmacology assays, including but not limited to surgical models, ICV/IT administration, stereotaxic injections, surgical recovery monitoring, and clinical scoring, to define procedural and welfare standards
• Support in vivo pharmacology studies by conducting broad, standardized assessments of functional, behavioral, and physiological endpoints across preclinical disease models, enabling robust evaluation of treatment-related effects
• Manage CRO partnerships and external study execution, extending the laboratory’s capacity and geographic reach, ensuring program timelines are maintained without compromising scientific standards
• Champion IACUC, AAALAC, and GLP compliance across the in vivo function

Translational PK/PD And Biomarker Support

• Execute target engagement marker assays, flow cytometry assays, cytokine/chemokine assays, and support histology/IHC coordination and molecular endpoint integration
• Contribute to the development of translational data packages by integrating PK, biomarker, and pharmacodynamic data under the direction of the Lab Head

Minimum Qualifications

• PhD in Pharmacology, Neuroscience, Immunology, Biology, Physiology or other life science discipline with 4+ years of hands-on in vivo pharmacology experience

OR

• Master’s degree in Pharmacology, Neuroscience, Immunology, Biology, Physiology or other life science discipline with 6+ years of hands-on in vivo pharmacology experience

OR

• Bachelor’s degree in Pharmacology, Neuroscience, Immunology, Biology, Physiology or other life science discipline with 8+ years of hands-on in vivo pharmacology experience

Preferred Qualifications

• Ph.D. in Reproductive Biology, Endocrinology, Pharmacology, Physiology, or Neuroendocrinology
• Demonstrated expertise in disease model execution, relevant routes of administration, and translational PK/PD
• Experience with developing and validating reproductive endocrine models including superovulation, folliculogenesis, luteinisation, corpus luteum maintenance, and/or testicular steroidogenesis
• Significant experience in a pharmaceutical or biotech R&D environment
• Significant experience with protein-based and molecular biomarker assays, specifically Flow Cytometry and including other assay formats including ELISA, MSD, cytokine/chemokine panels, target engagement markers, Olink, NULISA, etc

Pay Range for this position: $90,400 - $135,700

Benefits offered by the Company include health insurance, paid time off (PTO), retirement contributions, and other perquisites.

What we offer:

We are curious minds that come from a broad range of backgrounds, perspectives, and life experiences. We believe that this variety drives excellence and innovation, strengthening our ability to lead in science and technology. We are committed to creating access and opportunities for all to develop and grow at your own pace. Join us in building a culture of inclusion and belonging that impacts millions and empowers everyone to work their magic and champion human progress!