Senior Scientist, LNP Discovery Biology

CHEManager International; Billerica (MA); On-site; USD 95,000 - 144,000; Full time

Benefits offered by this job

Health insurance

Paid time off (PTO)

Retirement contributions

Other perquisites

Job summary

EMD Serono is seeking a Senior Scientist, LNP Discovery Biology to support the targeted delivery program in Neuroscience & Immunology. You will perform in vitro and ex vivo work, develop assays, and collaborate across groups to advance candidate molecules.

The role combines bench science with data interpretation and presentation to project teams. The position emphasizes hands-on experience with human immune cells, multicolor flow cytometry, and in vivo studies using humanized mouse models,

Qualifications

• Bachelor's degree in Life Sciences with 8+ years industry experience.
• 1+ years of experience with primary human immune cell culture and multicolor flow cytometry.
• PhD/MD or relevant advanced degree with corresponding years of industry experience.

Responsibilities

• Execute in vitro and ex vivo studies for the LNP delivery platform using human cells.
• Develop, qualify, and troubleshoot new assays for CROs and internal use.
• Design and run multicolor flow cytometry panels and generate core readouts.

Skills

Primary human immune cell culture

Multicolor flow cytometry

Cell-based assays development

In vivo studies

Data analysis and presentation

Laboratory record-keeping

Education

Bachelor's Degree in Immunology/Cell Biology/Molecular Biology

Master's Degree in Immunology/Cell Biology/Molecular Biology

PhD in Immunology/Cell Biology/Molecular Biology

Tools

LNP delivery systems

CAR biology techniques

NSG mouse models

Job description

Work Your Magic with us! Start your next chapter and join EMD Serono.

Ready to explore, break barriers, and discover more? We know you've got big plans - so do we! Our colleagues across the globe love innovating with science and technology to enrich people's lives with our solutions in Healthcare, Life Science, and Electronics. Together, we dream big and are passionate about caring for our rich mix of people, customers, patients, and planet. That's why we are always looking for curious minds that see themselves imagining the unimaginable with us.

United As One for Patients, our purpose in Healthcare is to help create, improve and prolong lives. We develop medicines, intelligent devices and innovative technologies in therapeutic areas such as Oncology, Neurology and Fertility. Our teams work together across 6 continents with passion and relentless curiosity in order to help patients at every stage of life. Joining our Healthcare team is becoming part of a diverse, inclusive and flexible working culture, presenting great opportunities for personal development and career advancement across the globe.

This role does not offer sponsorship for work authorization. External applicants must be eligible to work in the US.

Your Role

The Senior Scientist, LNP Discovery Biology position is a hands-on bench role supporting the LNP Discovery platform within the Research Unit Neuroscience & Immunology (N&I). You will execute the in vitro and ex vivo work that drives candidate selection and develop assays the program depends on. The role sits at the interface of LNP delivery and immunology and collaborates across groups to progress a differentiated targeted delivery platform. This is a laboratory-based role where you will run your own experiments, interpret your own data, and present it to the project team, working closely with Principal Scientist's across the department and the wider group.

• Execute in vitro and ex vivo studies in support of the targeted LNP delivery platform, including primary human T cell and PBMC assays for transfection efficiency, CAR expression, and functional activity.
• Develop, qualify, and troubleshoot new assays, and document them to a standard other scientists and CROs can follow.
• Design and run multicolor flow cytometry panels, and generate the core readouts in support of the targeted delivery platform.
• Support in vivo studies in humanized mouse models (PBMC- and huCD34+-engrafted NSG), including sample processing, bleed and tissue collection, and endpoint analysis; contribute to study design discussions.
• Analyze, interpret, and present your data in group and project team meetings, with clear figures and a defensible interpretation.
• Maintain rigorous records: electronic lab notebook, assay protocols, reagent and sample tracking, and the quality standards the program's data packages rest on.
• Partner with formulation and lipid chemistry colleagues on candidate characterization, and with CRO and partner contacts on sample logistics and data transfer.
• Train and support research associates and junior scientists on assays and techniques you own.

Who You Are

Minimum Qualifications:

• Bachelors Degree in Immunology, Cell Biology, Molecular Biology or other Life Science discipline.
• 8+ years of industry experience.
• 1+ years of experience with primary human immune cell culture, multicolor flow cytometry, developing and troubleshooting cell-based assays, and supporting in vivo studies.

OR

• Master's Degree in Immunology, Cell Biology, Molecular Biology other Life Science discipline.
• 6+ years of industry experience.
• 1+ years of experience with primary human immune cell culture, multicolor flow cytometry, developing and troubleshooting cell-based assays, and supporting in vivo studies.

OR

• PhD in Immunology, Cell Biology, Molecular Biology, other Life Science discipline.
• 2+ years of industry experience.1+ years of experience with primary human immune cell culture, multicolor flow cytometry, developing and troubleshooting cell-based assays, and supporting in vivo studies.

Preferred Qualifications

• Experience with LNP or other nanoparticle delivery systems, including mRNA cargo and in vitro potency assessment.
• Experience with CAR biology or cell therapy, including CAR detection reagents and the readouts that distinguish real pharmacology from artifact.
• Experience with humanized mouse models (PBMC- or huCD34+-engrafted NSG), including engraftment monitoring.
• Prior work on B cell depletion, autoimmune indications, or CD19/CD20-directed therapies.
• Comfort in a fast-moving, cross-functional environment where the data and the slides are often due the same week.
• Hands-on experience with primary human immune cell culture - T cell isolation, activation, and expansion - and the functional assays that go with it.
• Strong practical command of multicolor flow cytometry: panel design, compensation, gating strategy, and the failure modes of each.
• Experience developing and troubleshooting cell-based assays independently, rather than only running established protocols.
• Experience supporting in vivo studies, including sample processing and endpoint analysis from mouse models.
• Careful, well-documented laboratory practice and comfort working to agreed protocols and quality standards.
• Clear communication of data and interpretation, including presenting at group and project team meetings.

Pay Range for this position: $94,600-$144,100

The offer range represents the anticipated low and high end of the base pay compensation for this position. The actual compensation offered will be determined by factors such as location, level of experience, education, skills, and other job-related factors. Position may be eligible for sales or performance-based bonuses. Benefits offered by the Company include health insurance, paid time off (PTO), retirement contributions, and other perquisites.

What we offer:

We are curious minds that come from a broad range of backgrounds, perspectives, and life experiences. We believe that this variety drives excellence and innovation, strengthening our ability to lead in science and technology. We are committed to creating access and opportunities for all to develop and grow at your own pace. Join us in building a culture of inclusion and belonging that impacts millions and empowers everyone to work their magic and champion human progress!