Scientist II, Antisense/siRNA and Peptide Purification

Biogen, Inc.; Cambridge (MA); On-site; USD 117,000 - 157,000; Full time

Benefits offered by this job

Medical Insurance

Dental Vision

Wellness reimbursement

Paid time off & holidays

401(k) plan

Stock purchase plan

Tuition reimbursement

Job summary

Biogen is seeking a Scientist II to join the Technical Development team in Cambridge, MA, focusing on oligonucleotide and peptide purification. You will design, develop, and scale robust purification processes from early development to commercial, using data-driven DoE to define control strategies and enable tech transfers into GMP manufacturing.

You will contribute to regulatory documentation and collaborate with multidisciplinary teams to deliver scalable, high-quality processes that support

Qualifications

• Ph.D. degree in chemical engineering, chemistry, or a related science with 0-3 years of experience
• Master’s degree in chemical engineering, chemistry, or a related science with 4+ years of experience in pharmaceutical or biotech settings
• Bachelor’s degree in chemical engineering, chemistry, or a related science with 6+ years of relevant experience in pharmaceutical or biotech settings
• Experience in purification process development, preferably in an industrial environment
• Strong analytical skills and statistical analysis expertise
• Proficiency in technical writing and presenting technical data

Responsibilities

• Design, develop, and scale purification processes across development stages (early development through commercial)
• Apply data-driven approaches (e.g., DoE) to characterize processes and define robust control strategies
• Lead or support technology transfer of processes into GMP manufacturing
• Troubleshoot process challenges and drive continuous improvement in process performance
• Collaborate with Manufacturing, Analytical, Quality, Non-Clinical, and Regulatory teams to enable program advancement
• Author technical reports and contribute to CMC sections of regulatory filings and respond to agency questions

Skills

Analytical skills

Statistical analysis

Technical writing

DoE design of experiments

Education

Ph.D. in chemical engineering/chemistry

Master’s in chemical engineering/chemistry

Bachelor’s in chemical engineering/chemistry

Job description

About This Role

About This Role At Biogen, we are advancing science to transform patients’ lives. We are seeking a highly motivated Scientist II to join our Technical Development team in Cambridge, MA, focused on oligonucleotide (Antisense/siRNA) and Peptide Purification. This is an exciting opportunity to design and develop robust, scalable purification processes that directly impact clinical and commercial therapeutics. You will play a key role in advancing next-generation modalities by bridging early development with manufacturing, working in a highly collaborative, cross-functional environment. Your work will contribute to building state-of-the-art platform processes that improve product quality, scalability, and efficiently enabling delivery of innovative therapies to patients.

Who We Are:

We are a team of chemists and chemical engineers engaged in the design of innovative processes which supply new medicines to patients. We focus on developing safe, economical, sustainable, cost-effective, and robust processes to support clinical trials and the launch of new medicines across various drug modalities. We are driven by first principles science, data-driven decision-making, and collaborative teamwork.

What You’ll Do:

Design, develop, and scale purification processes across development stages (early development through commercial). Apply data-driven approaches (e.g., DoE) to characterize processes and define robust control strategies. Lead or support technology transfer of processes into GMP manufacturing. Troubleshoot process challenges and drive continuous improvement in process performance. Collaborate with Manufacturing, Analytical, Quality, Non-Clinical, and Regulatory teams to enable program advancement. Author technical reports and contribute to CMC sections of regulatory filings and respond to agency questions.

Who You Are:

You are a hands‑on purification scientist who thrives in a dynamic, team‑oriented environment. You possess strong analytical skills, and a keen ability to apply statistical analysis to complex data. You have a natural curiosity and a passion for process development. Your technical writing and communication skills are excellent, enabling you to effectively present technical data and contribute to regulatory documentation.

Required Skills

Ph.D. degree in chemical engineering, chemistry, or a related science with 0-3 years of experience

Master’s degree in chemical engineering, chemistry, or a related science with 4+ years of experience in pharmaceutical or biotech settings.

Bachelor’s degree in chemical engineering, chemistry, or a related science with 6+ years of relevant experience in pharmaceutical or biotech settings.

Experience in purification process development, preferably in an industrial environment.

Strong analytical skills and statistical analysis expertise.

Proficiency in technical writing and presenting technical data.

Preferred Skills

• Experience in developing processes for oligonucleotides, peptides, and/or proteins.
• Familiarity with GMP manufacturing processes.
• Collaborative mindset with experience working in cross-functional teams.

Job Level: Management

Additional Information

The base compensation range for this role is: $117,000.00-$157,000.00

Base salary offered is determined through an analytical approach utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity.

Regular employees are eligible to receive both short term and long-term incentives, including cash bonus and equity incentive opportunities, designed to reward recent achievements and recognize your future potential based on individual, business unit and company performance.

In addition to compensation, Biogen offers a full and highly competitive range of benefits designed to support our employees’ and their families physical, financial, emotional, and social well‑being; including, but not limited to:

• Medical, Dental, Vision, & Life insurances
• Fitness & Wellness programs including a fitness reimbursement
• Short- and Long-Term Disability insurance
• A minimum of 15 days of paid vacation and an additional end‑of‑year shutdown time off (Dec 26-Dec 31)
• Up to 12 company paid holidays + 3 paid days off for Personal Significance
• 80 hours of sick time per calendar year
• Paid Maternity and Parental Leave benefit
• 401(k) program participation with company matched contributions
• Employee stock purchase plan
• Tuition reimbursement of up to $10,000 per calendar year
• Employee Resource Groups participation

Why Biogen?

We are a global team with a commitment to excellence, and a pioneering spirit. As a mid‑sized biotechnology company, we provide the stability and resources of a well‑established business while fostering an environment where individual contributions make a significant impact. Our team encompasses some of the most talented and passionate achievers who have unparalleled opportunities for learning, growth, and expanding their skills. Above all, we work together to deliver life‑changing medicines, with every role playing a vital part in our mission. Caring Deeply. Achieving Excellence. Changing Lives. At Biogen, we are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients we serve. We know that diverse backgrounds, cultures, and perspectives make us a stronger and more innovative company, and we are focused on building teams where every employee feels empowered and inspired. Read on to learn more about Biogen.

All qualified applicants will receive consideration for employment without regard to sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information or any other basis protected by federal, state or local law.

Biogen is an E-Verify Employer in the United States.

As Biogen recently acquired Apellis, you can find additional open jobs on our Apellis website here.