Scientist II (Lentiviral Production)

R&D Partners; South San Francisco (CA); In loco; USD 84.000 - 87.000; Tempo pieno

Vantaggi offerti da questo lavoro

Medical insurance

401k plan

Employee Assistance Program

Long-term disability

Weekly payroll

Online timecard approval

Descrizione del lavoro

R&D Partners in South San Francisco, CA is seeking a Scientist II for a 12-month contract focused on research-scale lentiviral vector production, characterization, and assay development. The role supports preclinical in vivo studies through collaboration with teams, with no animal studies conducted by the candidate.

The successful candidate will have strong experimental judgment, hands-on vector production expertise, and cell-based analytics, contributing to advancing research programs in a

Competenze

• Bachelor's degree with 5+ years of industry experience or PhD in a related field.
• Hands-on experience with lentiviral vector production and characterization.
• Proficiency in aseptic mammalian cell culture and primary human immune cells (preferably T cells).
• Experience developing, optimizing, and troubleshooting molecular or cell-based analytical assays.
• Technical proficiency in flow cytometry and quantitative assay platforms (qPCR/ddPCR).
• Ability to design experiments independently and interpret data.

Mansioni

• Execute and optimize research-scale lentiviral vector production workflows, including suspension culture transitions.
• Produce and characterize research-grade lentiviral vectors for in vitro evaluation and preclinical studies.
• Develop, optimize, and execute molecular and cell-based assays to assess vector quality, titer, and functional activity.
• Perform primary human cell culture and engineering studies to support delivery platforms for in vivo applications.
• Apply flow cytometry to assess transduction efficiency, CAR expression, and cell phenotype.
• Collaborate with project teams to define material requirements and production timelines.

Conoscenze

Lentiviral vector production

Cell-based analytics

Flow cytometry

Experimental design

Data interpretation

Collaboration

Formazione

Bachelor's degree in Immunology, Virology, Molecular Biology, Bioengineering, Cell Biology, or related

PhD in Immunology, Virology, Molecular Biology, Bioengineering, Cell Biology, or related

Strumenti

qPCR

ddPCR

Flow cytometer

Descrizione del lavoro

We are hiring a Scientist II to support our biotechnology client's Cell Therapy department. This hands‑on, laboratory‑based role will focus on research‑scale lentiviral vector production, vector characterization, and analytical assay development. The Scientist may also generate and characterize materials for use in preclinical in vivo studies conducted by collaborating teams. This position does not involve conducting animal studies. The successful candidate will bring strong experimental judgment, technical expertise in vector production and cell‑based analytics, and a collaborative approach to advancing research programs.

This is a 12 month contract position in South San Francisco, CA.

Responsibilities

• Execute and optimize research‑scale lentiviral vector production workflows, including approaches that support increased production capacity and transition to suspension culture.
• Produce and characterize research‑grade lentiviral vectors for in vitro evaluation and, as needed, to support preclinical in vivo studies.
• Develop, optimize, and execute molecular and cell‑based assays to assess vector quality, titer, gene delivery, CAR expression, and functional activity.
• Perform primary human cell culture and engineering studies to support evaluation of delivery platforms for in‑vivo cell therapy applications.
• Apply flow cytometry to assess transduction efficiency, CAR expression, and cell phenotype.
• Collaborate with project teams to define material requirements, coordinate production timelines, and provide supporting analytical data.
• Independently plan experiments, troubleshoot technical challenges, and interpret results in collaboration with project team members.
• Analyze and communicate findings through clear experimental summaries and presentations at internal scientific meetings.
• Maintain accurate and timely electronic laboratory records, document methods, and contribute to reproducible workflows.
• Support laboratory operations, including equipment onboarding and maintenance, and adhere to applicable biosafety, laboratory safety, and training requirements.

Qualifications

• Bachelor's degree and 5 years industry experience, or PhD in Immunology, Virology, Molecular Biology, Bioengineering, Cell Biology, or a related discipline.
• Hands‑on experience with lentiviral vector production and characterization.
• Strong proficiency in aseptic mammalian cell culture and experience working with primary human immune cells, preferably T cells.
• Experience developing, optimizing, and troubleshooting molecular or cell‑based analytical assays.
• Technical proficiency in flow cytometry and at least one quantitative molecular assay platform, such as qPCR or ddPCR.
• Demonstrated ability to independently design experiments, critically interpret data, and resolve technical challenges.
• Strong organizational, documentation, and communication skills, with the ability to manage concurrent experiments and collaborate effectively.
• Preferred Qualifications
• Three or more years of relevant post‑graduate research experience in biotechnology, pharmaceutical research, or an academic setting.
• Experience producing or characterizing gene delivery vectors for in‑vivo CAR T or related preclinical research programs.
• Experience with suspension-based lentiviral vector production, scale‑up, or process development.
• Experience with CAR T‑cell functional assays and multiparameter flow cytometry.

Pay

• $60.75-$63.11

Why Choose R&D Partners?

As an employee, you have access to a comprehensive benefits package including:

• Medical insurance – PPO, HMO & HSA
• 401k plan
• Employee Assistance Program
• Long‑term disability
• Weekly payroll
• Online timecard approval

R&D Partners is a global functional service provider and strategic staffing resource specializing in scientific, clinical research & engineering. We provide job opportunities within major pharmaceutical, biopharmaceutical, biotechnology, and medical device companies.

R&D Partners is an equal‑opportunity employer.