Scientist II

Tailored Management; South San Francisco (CA); On-site; USD 50,000 - 66,000; Full time

Benefits offered by this job

Medical Coverage

Dental Insurance

Vision Insurance

Short-Term Disability

Long-Term Disability

Life & AD&D Insurance

EAP

Job summary

Tailored Management in South San Francisco, CA seeks a Scientist II to develop LVV and AAV production platforms. You will optimize workflows, perform cell culture and transfection, and drive DOE-based improvements to yield, throughput, and quality.

The role involves downstream purification, viral vector characterization, data analysis, and cross-functional collaboration to advance research programs.

Qualifications

• MS or PhD in life sciences or related field.
• Minimum 3 years of lab or industry experience.
• Hands-on experience with ex vivo CAR-T cell engineering using lentiviral vectors.
• Proficient in mammalian cell culture, transfection, and molecular biology techniques.

Responsibilities

• Develop and optimize high-throughput LVV and AAV production workflows.
• Perform mammalian cell culture, transfection, and viral vector production.
• Apply DOE to improve yield, throughput, and consistency.
• Develop downstream purification including filtration, TFF, and chromatography.
• Characterize viral vectors and perform quality control assays.
• Analyze data, maintain records/inventory, and prepare SOPs/reports.
• Collaborate with cross-functional teams to troubleshoot processes.

Skills

Mammalian cell culture

Transfection

Molecular biology techniques

PCR/qPCR/ddPCR/dPCR/Western blot

DOE methodologies

Data analysis & documentation

Viral vector production

AAV/LVV workflows

Automation & high-throughput workflows

Flow cytometry

Education

MS or PhD in Cell Biology, Molecular Biology, Virology, Biochemistry, Bioengineering, Genetics, or related field

Tools

Automated liquid handling systems

Parallel bioreactor platforms

Job description

Scientist II – Viral Vector Process Development
Location: South San Francisco, CA
Pay Rate: $36–$48/hour
Benefits: Weekly pay, medical, dental, vision, and disability coverage

Position Overview

We are seeking a motivated and collaborative Scientist II to support the development and optimization of lentiviral vector (LVV) and adeno-associated virus (AAV) production platforms. This role focuses on improving viral vector yield, production throughput, and quality to support research, screening, and therapeutic pipeline development.

Key Responsibilities

• Develop and optimize high-throughput LVV and AAV production workflows using automated liquid handling systems and parallel bioreactor platforms.
• Perform mammalian cell culture, transient transfection, viral vector production, and upstream process optimization.
• Apply Design of Experiments (DOE) methodologies to improve production yield, efficiency, and consistency.
• Develop downstream purification processes, including filtration, tangential flow filtration (TFF), and chromatography.
• Perform viral vector characterization and quality control using molecular biology and analytical techniques.
• Analyze experimental data, maintain laboratory records and inventory, and prepare SOPs, technical reports, and presentations.
• Collaborate with cross-functional research teams to troubleshoot processes and improve experimental outcomes.

Required Qualifications

• MS or PhD in Cell Biology, Molecular Biology, Virology, Biochemistry, Bioengineering, Genetics, or a related field.
• At least 3 years of laboratory research or industry experience.
• Hands-on experience with ex vivo CAR-T cell engineering using lentiviral vectors.
• Proficiency in mammalian cell culture, transient plasmid transfection, and molecular biology techniques, such as PCR, qPCR, ddPCR, dPCR, or Western blot.
• Strong analytical, data interpretation, documentation, and communication skills.

Preferred Qualifications

• Experience producing lentiviral or AAV vectors in adherent or suspension cell systems.
• Knowledge of upstream and downstream process development and viral vector purification.
• Experience with DOE, automated liquid handling systems, and high-throughput workflows.
• Familiarity with flow cytometry, electronic laboratory notebooks, and BSL-2 laboratory operations.

At Tailored Management, we help people get jobs and take pride in their work, so we better take pride in ours too. Not every company has the opportunity to meaningfully and directly impact individuals in a way that makes their lives tangibly better. To better support our employees, we offer a wide variety of benefit options to support you. We offer:

• Medical Coverage – HDHP, PPO, and Surest plan options
• Minimum Essential Coverage (MEC)
• Dental Insurance
• Vision Insurance
• Short-Term Disability (STD)
• Long-Term Disability (LTD)
• Life & AD&D Insurance
• Critical Illness Insurance
• Accident Insurance
• Employee Assistance Program (EAP)

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