Scientist I, Proteomics

Vividion Therapeutics, Inc.; San Diego (CA); On-site; USD 115,000 - 125,000; Full time

Benefits offered by this job

401k with company match

Medical, dental, vision insurance

Job summary

Vividion Therapeutics, Inc. in San Diego seeks a Scientist specialized in chemical proteomics to deploy MS-based workflows and identify druggable targets. The role involves hands-on mass spectrometry, proteomics data analysis, and collaboration to advance ligand discovery.

The successful candidate will apply chemical biology workflows with mammalian cell culture, contributing to target engagement studies and Proteome-wide profiling.

Qualifications

• PhD in mass-spectrometry based proteomics or chemical biology.
• Experience operating Orbitrap MS and nano-LC systems.
• Experience analyzing proteomics datasets with MS software.
• Cell culture of mammalian cells; transfections and stable lines.
• Knowledge of cell-based assays for tool compounds.

Responsibilities

• Support ligand discovery against high-impact targets.
• Apply proteomic, cellular, and biochemical methods to characterize interactions.
• Collaborate with cross-functional teams across biology and chemistry.
• Maintain rigorous data quality and documentation for research findings.

Skills

Mass spectrometry

Proteomics data analysis

Chemical biology

Mammalian cell culture

Ligand discovery

Education

PhD in proteomics/chemical biology

Tools

Orbitrap MS

Nano-LC systems

MS data analysis software

Job description

Description

Company Overview: Vividion is a next generation biotechnology company based in San Diego that is leveraging its proprietary chemical proteomics platform to conduct proteome‑wide footprinting of drug‑protein interactions with unprecedented breadth and precision. Our technology allows us to screen, identify and optimize novel drugs that selectively bind virtually any protein, including proteins previously considered “undruggable”. Our pipeline and emerging programs reflect a matured and productive platform capable of delivering first in class drugs utilizing novel mechanisms of action (allosteric inhibitors, protein‑protein interaction inhibitors, functional activators, degraders etc.) against undruggable targets in the oncology and immunology space.

We prize scientific excellence, creativity, team players and we are committed to continued innovation. We have worked hard to create a collaborative and dynamic work culture where your ideas and discoveries are valued and will have an impact. We are growing and there are opportunities for mentorship and career progression.

Vividion has been recognized as a Top Workplace by The San Diego Union‑Tribune from 2022 to 2025.

Job Summary

We are seeking a scientist who is passionate about deploying chemical proteomics to interrogate biology and identify novel opportunities for small molecule drug discovery. The successful candidate will have hands‑on experience in mass‑spectrometry‑based proteomics and chemical biology workflows to characterize the interaction of small molecule ligands with their protein targets. This position will be responsible for supporting efforts to enable ligand discovery against high‑impact targets using a combination of proteomic, cellular and biochemical methods.

Requirements

Education and Experience requirements:

• Ph.D. (or equivalent experience) in mass‑spectrometry based proteomics or chemical biology
• Experience operating and maintaining orbitrap mass spectrometers and associated nano‑LC systems
• Demonstrated experience in acquiring, analyzing and interpreting proteomics datasets and familiarity with common MS software suites
• Experience preparing samples for MS analysis utilizing workflows that include peptide enrichment, protein enrichment or PTM enrichment
• Proficiency in mammalian cell culture, including cell line maintenance, transient transfections, stable cell line generation
• Understanding of cell-based assays for characterization of the functional effects of tool compounds on biological pathways, protein‑protein interactions, and cellular proliferation

Key Attributes

• Excellent communication and presentation skills within a setting of cross‑functional program teams
• Ability to prioritize tasks and manage time effectively in a dynamic, fast‑paced research environment
• Attention to detail and good organization and documentation habits
• Self‑motivated problem solver with a strong sense of independently developing experimental strategies to address key needs

Pay & Benefits

The anticipated annual base salary for this position ranges from $115,000 to $125,000 depending on relevant skills, experience, and education. In addition, this position is eligible for target bonus, long‑term‑incentives, 401k retirement savings plan with company match, and a comprehensive benefits package which includes medical, dental, vision, life, and disability insurance.

EEO & Employment Eligibility

Vividion Therapeutics, Inc. is an equal opportunity employer. All applicants will receive consideration for employment without regard to disability or veteran status.

Privacy Policy

The protection of your personal information is a commitment we take seriously. For information regarding our Privacy Policy (CA candidates) please visit https://vividion.com/publication/privacy-noticeforcalifornia-candidates/.