Scientist I, Proteomics

Vividion Therapeutics. Inc.; San Diego (CA); On-site; USD 115,000 - 125,000; Full time

Benefits offered by this job

401k with company match

Medical insurance

Dental insurance

Vision insurance

Life insurance

Disability insurance

Job summary

Vividion Therapeutics, Inc. seeks a scientist passionate about deploying chemical proteomics to advance small molecule drug discovery.

You will apply mass-spectrometry-based proteomics and chemical biology workflows to study ligand–protein interactions and support ligand discovery against high-impact targets. The role requires hands-on MS experience, mammalian cell culture, and the ability to work across cross-functional teams in a fast-paced biotech setting.

Qualifications

• PhD in mass spectrometry-based proteomics or chemical biology.
• Experience operating Orbitrap MS and nano-LC systems.
• Demonstrated ability to acquire, analyze and interpret proteomics datasets.

Responsibilities

• Support ligand discovery against high-impact targets using proteomic, cellular and biochemical methods.
• Characterize interactions of small molecule ligands with protein targets using MS-based workflows.
• Collaborate with cross-functional program teams to enable drug discovery.

Skills

Mass spectrometry analysis

Mammalian cell culture

Cross-functional collaboration

Data analysis

Education

PhD in proteomics or chemical biology

Tools

Orbitrap MS

Nano-LC systems

Job description

Description

Company Overview

Vividion is a next generation biotechnology company based in San Diego that is leveraging its proprietary chemical proteomics platform to conduct proteome-wide footprinting of drug-protein interactions with unprecedented breadth and precision. Our technology allows us to screen, identify and optimize novel drugs that selectively bind virtually any protein, including proteins previously considered “undruggable”. Our pipeline and emerging programs reflect a matured and productive platform capable of delivering first in class drugs utilizing novel mechanisms of action (allosteric inhibitors, protein-protein interaction inhibitors, functional activators, degraders etc.) against undruggable targets in the oncology and immunology space.

We prize scientific excellence, creativity, team players and we are committed to continued innovation. We have worked hard to create a collaborative and dynamic work culture where your ideas and discoveries are valued and will have an impact. We are growing and there are opportunities for mentorship and career progression.

Vividion has been recognized as a Top Workplace by The San Diego Union-Tribune from 2022 to 2025.

Job Summary

We are seeking a scientist who is passionate about deploying chemical proteomics to interrogate biology and identify novel opportunities for small molecule drug discovery. The successful candidate will have hands‑on experience in mass‑spectrometry-based proteomics and chemical biology workflows to characterize the interaction of small molecule ligands with their protein targets. This position will be responsible for supporting efforts to enable ligand discovery against high-impact targets using a combination of proteomic, cellular and biochemical methods.

Requirements

Education and Experience requirements

• Ph.D. (or equivalent experience) in mass‑spectrometry based proteomics or chemical biology
• Experience operating and maintaining orbitrap mass spectrometers and associated nano‑LC systems
• Demonstrated experience in acquiring, analyzing and interpreting proteomics datasets and familiarity with common MS software suites
• Experience preparing samples for MS analysis utilizing workflows that include peptide enrichment, protein enrichment or PTM enrichment
• Proficiency in mammalian cell culture, including cell line maintenance, transient transfections, stable cell line generation
• Understanding of cell-based assays for characterization of the functional effects of tool compounds on biological pathways, protein-protein interactions, and cellular proliferation

Key Attributes

• Excellent communication and presentation skills within a setting of cross‑functional program teams
• Ability to prioritize tasks and manage time effectively in a dynamic, fast‑paced research environment
• Attention to detail and good organization and documentation habits
• Self‑motivated problem solver with a strong sense of independently developing experimental strategies to address key needs

Pay & Benefits

The anticipated annual base salary for this position ranges from $115,000 to $125,000 depending on relevant skills, experience, and education. In addition, this position is eligible for target bonus, long‑term incentives, 401k retirement savings plan with company match, and a comprehensive benefits package which includes medical, dental, vision, life, and disability insurance.

EEO & Employment Eligibility

Vividion Therapeutics, Inc. is an equal opportunity employer. All applicants will receive consideration for employment without regard to disability or veteran status.

Privacy Policy

The protection of your personal information is a commitment we take seriously. For information regarding our Privacy Policy (CA candidates) please visit https://vividion.com/publication/privacy-noticeforcalifornia-candidates/.