Senior Research Associate, Pharmacology (Contractor)

Vividion Therapeutics, Inc; San Diego (CA); On-site; USD 52,000 - 62,000; Full time

Job summary

Vividion Therapeutics, Inc. in San Diego is seeking a scientist to provide in vivo and ex vivo support for pre-clinical drug development, focusing on inflammatory and autoimmune diseases.

The role requires independent study execution, data analysis, and clear communication within cross-functional teams. Responsibilities include designing in vivo experiments, PK/PD studies, administering compounds to mice, collecting samples, and performing ex vivo assays such as MSD, ELISA, Luminex; experience

Qualifications

• BS with 6+ years’ experience in vivo in biotech/pharma.
• Rodent dosing routes (PO, IV, IP, SC), blood collection, necropsy, and organ collection are required.
• Experience with flow cytometry, qPCR, MSD, Luminex, and ELISA is highly desired.
• Rodent surgery experience is a plus.

Responsibilities

• Design, plan, and execute in vivo experiments; address mechanism-of-action in follow-on ex vivo analyses.
• Execute PK/PD, target engagement, efficacy, or MOA studies to support pre-clinical and discovery programs.
• Administer small molecule compounds to mice, measure endpoints and collect samples.
• Perform ex vivo analysis on sera and/or tissues; assays include MSD, ELISA, Luminex, flow cytometry, and qPCR.
• Analyze, interpret, and visualize experimental data and maintain accurate records.
• Work independently and with a multidisciplinary pharmacology team.
• Collect, organize and present data in project team meetings.

Skills

In vivo pharmacology

Data analysis

Cross-functional collaboration

Education

BS in Biology/Immunology/Pharmacology or related field

Tools

Flow cytometry

qPCR

MSD

Luminex

ELISA

Job description

Description

*NOTE: This is a 6-month, temporary position.*

Company Overview:

Vividion is a next generation biotechnology company based in San Diego that is leveraging its proprietary chemical proteomics platform to conduct proteome-wide footprinting of drug-protein interactions with unprecedented breadth and precision. Our technology allows us to screen, identify and optimize novel drugs that selectively bind virtually any protein, including proteins previously considered “undruggable”. Our pipeline and emerging programs reflect a matured and productive platform capable of delivering first in class drugs utilizing novel mechanisms of action (allosteric inhibitors, protein-protein interaction inhibitors, functional activators, degraders etc.) against undruggable targets in the oncology and immunology space.

We prize scientific excellence, creativity, team players and we are committed to continued innovation. We have worked hard to create a collaborative and dynamic work culture where your ideas and discoveries are valued and will have an impact. We are growing and there are opportunities for mentorship and career progression.

Vividion has been recognized as a Top Workplace by The San Diego Union-Tribune from 2022 to 2025.

Job Summary:

The successful candidate will provide in vivo and ex vivo support for pre-clinical drug development and discovery efforts for treating inflammatory and autoimmune diseases. The role requires independent study execution, mechanistic investigation, data analysis, and effective communication of scientific findings within cross-functional project teams.

Requirements

Essential Duties and Responsibilities:

• Independently design, plan, and execute in vivo experiments; conduct follow on ex vivo analysis addressing drug mechanism-of-action.
• Execute pharmacokinetic / pharmacodynamic, target engagement, efficacy, or mechanism of action studies to support pre-clinical and discovery programs.
• Administer small molecule compounds to mice, measure endpoints (e.g., body/tissue weight) and collect blood/tissue for analysis.
• Perform ex vivo analysis on collected sera and/or tissues as required. Assays include and not limited to: MSD, ELISA, multiplex Immunoassay (LegendPlex), flow cytometry, and qPCR.
• Analyze, interpret, and visualize experimental data (Prism, Excel) and other data analysis tools and maintain accurate experimental records and organize scientific data in a clear and reproducible manner.
• Work both independently and collaboratively within a multidisciplinary pharmacology team.
• Collect, organize and present scientific/technical data (PowerPoint) internally and in project team meetings.

Education and Experience requirements:

• BS with 6+ years’ experience of in vivo in a biotechnology or pharmaceutical setting. Ideally the degree should be in Biology, Immunology, Pharmacology, or related field. Preference given to Immunology experience.
• Rodent dosing routes (PO, IV, IP, SC), blood collection (sub-mandibular, terminal cardiac), necropsy, and organ collection are required.
• Experience with the following techniques is highly desired: flow cytometry, qPCR, MSD, Luminex, and ELISA.
• Rodent surgery experience is a plus.

Required Key Attributes:

• ffective troubleshooting and problem-solving skills.
• xcellent oral and written communication skills.
• Be an effective team player and strong individual contributor, flexible, and able to handle multiple tasks and deliver high-quality results under tight timelines.

Pay:

The hourly pay for this position ranges from $38.00 to $45.00 depending on relevant skills, experience, and education.

EEO & Employment Eligibility:

Vividion Therapeutics, Inc. is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other characteristic protected by applicable federal, state, or local laws.

Privacy Policy:

The protection of your personal information is a commitment we take seriously. For information regarding our Privacy Policy (CA candidates) please visit https://vividion.com/privacy-notice/.