Sr. Scientist

Digital Prospectors; Framingham (MA); On-site; USD 80,000 - 120,000; Full time

Job summary

Digital Prospectors in Framingham, Massachusetts is seeking a highly motivated Scientist/Senior Scientist to develop and implement advanced MALDI imaging technologies. This role involves collaborating with a talented team dedicated to the discovery and validation of biomarkers in areas such as cancer and neurodegenerative diseases.

The ideal candidate should have a Ph.D. in a relevant field and experience with HRAM mass spectrometers. Responsibilities include mentorship, data analysis, and communication of findings to various stakeholders.

Qualifications

• Hands-on experience preparing samples for MALDI imaging.
• Experience operating state-of-the-art HRAM mass spectrometers.
• Ability to develop and validate MALDI-based methods.
• Background in ion mobility-MS and small molecule analysis.
• Solid scientific training demonstrated through high-impact publications.

Responsibilities

• Drive research in qualitative and quantitative MALDI imaging analysis.
• Provide imaging data to support drug development.
• Mentor research associates and collaborate on experiments.
• Communicate findings to chemists, biologists, and clinicians.

Skills

MALDI imaging technology

Data analysis

Biochemistry

Chemistry

Organic chemistry

Systems biology

Education

Ph.D. in Chemistry, Biology, Biochemistry or related field

Tools

HRAM mass spectrometers

UHPLC-MS/MS

Job description

*Please no agencies. Direct employees currently authorized to work in the United States – no sponsorship available

Job Description

The highly motivated Scientist/Senior Scientist will develop and implement advanced MALDI imaging technologies to address important questions in the fields of biology, chemistry, and clinical medicine. This role involves collaborating with a team dedicated to the discovery and validation of biomarkers in diverse disease areas, including neurodegenerative diseases and cancer.

Essential Duties and Responsibilities

• Drive research in qualitative and quantitative MALDI imaging analysis of small molecules (lipids & metabolites), as well as targeted proteins using antibody-based technologies.
• Provide robust proof-of-principle and mechanism-of-action imaging data to support internal drug development and/or diagnostic pipelines.
• Mentor research associates/scientists and collaborate closely with analytical biochemistry, molecular biology, and computational research staff to design, plan, and perform experiments, collect data, and conduct data analysis.
• Communicate findings to a team of chemists, biologists and/or clinicians.

Qualifications

• Requires a Ph.D. degree in Chemistry, Biology, Biochemistry or a related field with hands‑on experience preparing samples for MALDI imaging and operating state‑of‑the‑art HRAM mass spectrometers. Relevant postdoctoral experience preferred.
• Ability to develop, optimize, and validate MALDI-based methods (tissue imaging and high‑throughput screening on MALDI target plates), including the evaluation of ionization matrices and optimization of mass spectrometric data acquisition strategies.
• A strong background in small molecule analysis and ion mobility‑MS, and some experience in organic chemistry, cell biology, signaling, and/or systems biology.
• Familiarity with sample preparation (liquid‑liquid extraction and SPE) and global analysis of lipids and metabolites by UHPLC‑MS/MS, including nontargeted (qualitative/semi-quantitative) and targeted (quantitative) analyses, on high‑resolution Orbitrap mass spectrometers and triple‑quadrupole mass spectrometers.
• Ability to work with an interdisciplinary team of biologists, chemists, and computational scientists to deeply characterize and understand the metabolomes, lipidomes and proteomes of cells, biofluids, and tissues.
• Demonstrated ability to analyze, interpret, and present data in a clear fashion.
• Solid scientific training/productivity as identified through high‑impact publications demonstrating creative thinking as well as innovative technical approaches.

POST-OFFER BACKGROUND CHECK IS REQUIRED. Digital Prospectors is an Equal Opportunity Employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, veteran status, or any other characteristic protected by law. Digital Prospectors affirms the right of all individuals to equal opportunity and prohibits any form of discrimination or harassment.