Scientist I, Large Molecule Bioanalysis LC-MS (Hybrid)

Neurocrine Biosciences

San Diego (CA)

On-site

USD 90,000 - 123,000

Full time

9 days ago

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Benefits offered by this job

Annual bonus

Equity-based LT incentive program

Retirement plan with company match

Paid vacation

Holiday and personal days

Health, dental, vision insurance

Job summary

Neurocrine Biosciences seeks a Scientist in Large Molecule Bioanalysis to support preclinical development of peptides, antibodies, proteins, ADCs, and other protein conjugates. The role emphasizes hands-on development and application of hybrid LC-MS/MS and LC-HRMS methods for quantitative bioanalysis.

You will perform immunoprecipitation, protein digestion, intact protein analysis, and contribute to biotransformation assessments of ADCs.

Qualifications

BS in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or related field with 2+ years of relevant experience in bioanalysis or MS.
Hands-on LC-MS analysis of proteins or peptides in plasma, serum, tissue, or other biological matrices.
Experience with hybrid LC-MS, immunoaffinity workflows, protein digestion, and high-resolution MS.
Experience with peptide/protein quantitation and bioanalytical method development.
Experience supporting preclinical bioanalysis and/or GLP method transfer is preferred.
Familiarity with Skyline, Analyst, TraceFinder, Chromeleon, or BioPharma Finder is beneficial.

Responsibilities

Develop and apply hybrid LC-MS/MS and LC-HRMS methods for peptide and protein quantitation in biological matrices.
Support bioanalysis of samples from preclinical PK/TK and other nonclinical studies.
Perform immunoprecipitation/immunoaffinity enrichment, protein digestion, and surrogate peptide quantitation.
Perform intact protein analysis, peptide mapping, and bottom-up LC-HRMS analysis.
Support biotransformation assessment of ADCs and protein conjugates using hybrid LC-HRMS.
Analyze, document, and communicate experimental results and contribute to method improvements.