Hybrid LC-MS Large Molecule Bioanalysis Scientist

Neurocrine Biosciences Inc.; San Diego (CA); On-site; USD 90,000 - 123,000; Full time

Benefits offered by this job

Annual bonus

Health benefits

Paid time off

Job summary

Neurocrine Biosciences in San Diego, CA seeks a Scientist in Large Molecule Bioanalysis to advance preclinical development of peptides, antibodies, proteins, ADCs, and other conjugates. The role focuses on hands-on development and application of hybrid LC-MS/MS and LC-HRMS methods for quantitative bioanalysis.

You will develop and apply methods for peptide and protein quantitation, support PK/TK studies, perform immunoprecipitation, digestion, and intact protein analysis, and contribute to

Qualifications

• BS in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or related field with 2+ years of relevant experience in bioanalysis.
• Hands-on LC-MS analysis of proteins/peptides in biological matrices.
• Experience with hybrid LC-MS workflows and high-resolution MS.
• Familiarity with preclinical bioanalysis and GLP method transfer is preferred.

Responsibilities

• Develop and apply hybrid LC-MS/MS and LC-HRMS methods for peptide and protein quantitation in biological matrices.
• Develop, optimize, and apply hybrid LC-MS/MS and LC-HRMS methods for peptide and protein quantitation in biological matrices.
• Support bioanalysis of samples from preclinical PK/TK and other nonclinical studies.
• Perform immunoprecipitation/immunoaffinity enrichment, protein digestion, and surrogate peptide quantitation.
• Perform intact protein analysis, peptide mapping, and bottom-up LC-HRMS analysis.
• Support biotransformation assessment of ADCs and protein conjugates using hybrid LC-HRMS.
• Analyze, document, and communicate experimental results and contribute to method improvements.

Skills

LC-MS analysis

Bioanalysis

Preclinical PK/TK

Education

BS in Analytical Chemistry

Tools

Skyline

Analyst

TraceFinder

Chromeleon

BioPharma Finder

Job description

Neurocrine Biosciences in San Diego, CA seeks a Scientist in Large Molecule Bioanalysis to advance preclinical development of peptides, antibodies, proteins, ADCs, and other conjugates. The role focuses on hands-on development and application of hybrid LC-MS/MS and LC-HRMS methods for quantitative bioanalysis.

You will develop and apply methods for peptide and protein quantitation, support PK/TK studies, perform immunoprecipitation, digestion, and intact protein analysis, and contribute to