Scientist I, Large Molecule Bioanalysis LC-MS

Neurocrine Biosciences; San Diego (CA); On-site; USD 90,000 - 123,000; Full time

Benefits offered by this job

Annual bonus

Equity-based LT incentive program

Retirement plan with company match

Paid vacation

Holiday and personal days

Health, dental, vision insurance

Job summary

Neurocrine Biosciences seeks a Scientist in Large Molecule Bioanalysis to support preclinical development of peptides, antibodies, proteins, ADCs, and other protein conjugates. The role emphasizes hands-on development and application of hybrid LC-MS/MS and LC-HRMS methods for quantitative bioanalysis.

You will perform immunoprecipitation, protein digestion, intact protein analysis, and contribute to biotransformation assessments of ADCs.

Qualifications

• BS in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or related field with 2+ years of relevant experience in bioanalysis or MS.
• Hands-on LC-MS analysis of proteins or peptides in plasma, serum, tissue, or other biological matrices.
• Experience with hybrid LC-MS, immunoaffinity workflows, protein digestion, and high-resolution MS.
• Experience with peptide/protein quantitation and bioanalytical method development.
• Experience supporting preclinical bioanalysis and/or GLP method transfer is preferred.
• Familiarity with Skyline, Analyst, TraceFinder, Chromeleon, or BioPharma Finder is beneficial.

Responsibilities

• Develop and apply hybrid LC-MS/MS and LC-HRMS methods for peptide and protein quantitation in biological matrices.
• Support bioanalysis of samples from preclinical PK/TK and other nonclinical studies.
• Perform immunoprecipitation/immunoaffinity enrichment, protein digestion, and surrogate peptide quantitation.
• Perform intact protein analysis, peptide mapping, and bottom-up LC-HRMS analysis.
• Support biotransformation assessment of ADCs and protein conjugates using hybrid LC-HRMS.
• Analyze, document, and communicate experimental results and contribute to method improvements.

Skills

LC-MS/MS

LC-HRMS

Bioanalysis

Immunoaffinity

Protein digestion

Peptide mapping

Bottom-up LC-HRMS

Immunoprecipitation

Preclinical PK/TK

High-resolution MS

Skyline

Analyst

TraceFinder

Chromeleon

BioPharma Finder

Education

BS in Analytical Chemistry

Biochemistry

Pharmaceutical Sciences

Related field

Tools

Skyline

Analyst

TraceFinder

Chromeleon

BioPharma Finder

Job description

Who We Are:Neurocrine Biosciences is a leading biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering, developing and commercializing life-changing treatments for patients with under-addressed neurological, psychiatric, endocrine and immunological disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, hyperphagia in Prader-Willi syndrome, endometriosis* and uterine fibroids*, as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For more than three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. For more information, visit neurocrine.com, and follow the company on LinkedIn, X, Facebook and YouTube. (*in collaboration with AbbVie)About the Role:We are seeking a Scientist in Large Molecule Bioanalysis to support preclinical development of peptides, antibodies, proteins, ADCs, and other protein conjugates. The role will primarily involve hands-on development and application of hybrid LC-MS/MS and LC-HRMS methods for quantitative bioanalysis and biotransformation assessment._Your Contributions (include, but are not limited to):Develop and apply hybrid LC-MS/MS and LC-HRMS methods for peptide and protein quantitation in biological matricesDevelop, optimize, and apply hybrid LC-MS/MS and LC-HRMS methods for peptide and protein quantitation in biological matricesSupport bioanalysis of samples from preclinical PK/TK and other nonclinical studiesPerform immunoprecipitation/immunoaffinity enrichment, protein digestion, and surrogate peptide quantitationPerform intact protein analysis, peptide mapping, and bottom-up LC-HRMS analysisSupport biotransformation assessment of ADCs and protein conjugates using hybrid LC-HRMSAnalyze, document, and communicate experimental results and contribute to method improvementsRequirements:BS in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or related field with 2+ years of relevant experience in bioanalysis or MS with some industry experience preferredHands-on experience with LC-MS analysis of proteins or peptides in plasma, serum, tissue, or other biological matricesExperience with hybrid LC-MS, immunoaffinity workflows, protein digestion, and high-resolution MSExperience with peptide/protein quantitation and bioanalytical method developmentExperience supporting preclinical bioanalysis and/or GLP method transfer is preferredFamiliarity with Skyline, Analyst, TraceFinder, Chromeleon, or BioPharma Finder is beneficial#LI-LS1Neurocrine Biosciences is an EEO/Disability/Vets employer.We are committed to building a workplace of belonging, respect, and empowerment, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don’t line up to exactly what we have outlined in the job description._The annual base salary we reasonably expect to pay is $89,800.00-$123,000.00. Individual pay decisions depend on various factors, such as primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience and skills. In addition, this position offers an annual bonus with a target of 20% of the earned base salary and eligibility to participate in our equity based long term incentive program. Benefits offered include a retirement savings plan (with company match), paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.