High-Throughput Protein Expression Scientist

Bristol-Myers Squibb; United States; On-site; USD 110,000 - 170,000; Full time

Benefits offered by this job

Comprehensive benefits

Health and welfare programs

Tuition assistance

Job summary

Bristol Myers Squibb is seeking a highly motivated Scientist to expand high-throughput biologics production capabilities within Discovery Biotherapeutics. The role focuses on scalable protein expression, purification, normalization, and characterization for antibody and multispecific biologics programs.

The candidate should have practical mammalian protein production experience, the ability to independently run experiments, analyze data, troubleshoot workflows, and deliver high-quality reagents.

Qualifications

• Bachelor's degree in biochemistry, bioengineering, structural biology, molecular biology, or related field with 5+ years experience; or Master's with 3+ years; or PhD with no additional experience.
• Hands-on protein expression and production workflows in mammalian systems.
• Experience with transient mammalian expression using HEK293, CHO, or related systems.
• Experience with purification technologies including affinity chromatography and quality assessment methods.
• Molecular biology background with cloning and high-throughput DNA fragment generation.
• Ability to design/execute experiments, analyze data, troubleshoot, and document.
• Ability to manage evolving priorities in a matrixed environment.
• Strong communication and collaboration; uphold lab safety and data integrity.

Responsibilities

• Execute high-throughput protein production workflows supporting antibody and other biologics discovery programs.
• Design, optimize, and troubleshoot transient mammalian expression workflows at micro- and mid-scale in HEK293/CHO systems.
• Perform automated protein purification, normalization, and quality assessment to deliver protein reagents.
• Operate and maintain liquid handlers, robotics, automated purification systems, and related instrumentation.
• Develop scalable workflows for expression, purification, normalization, and QC.
• Plan/execute experiments, analyze data, document results, communicate to cross-functional teams.
• Coordinate with Protein Sciences, Molecular Biology, Automation, Data Science, and Discovery Biology teams.
• Evaluate emerging technologies and miniaturization to improve throughput and reliability.
• Establish SOPs, quality standards, and data integrity practices.
• Lead/root-cause analysis for workflow/instrumentation issues; implement corrective actions.
• Drive continuous-improvement to reduce cycle time and expand platform capabilities.

Skills

High-throughput workflows

Mammalian expression

Protein purification

Automation experience

Data analysis

Troubleshooting

Cross-functional collaboration

Experimental design

Education

Bachelor's degree (Biochemistry/Bioengineering/related)

Master's degree or PhD (optional)

Tools

HEK293/CHO cell systems

Automated purification systems

Laboratory automation equipment

Job description

Bristol Myers Squibb is seeking a highly motivated Scientist to expand high-throughput biologics production capabilities within Discovery Biotherapeutics. The role focuses on scalable protein expression, purification, normalization, and characterization for antibody and multispecific biologics programs.

The candidate should have practical mammalian protein production experience, the ability to independently run experiments, analyze data, troubleshoot workflows, and deliver high-quality reagents.