Scientist 3: iPSC-to-T Cell Differentiation Expert

Genentech; San Francisco (CA); On-site; USD 103,000 - 192,000; Full time

Benefits offered by this job

Relocation benefits

Job summary

Genentech’s Cell Therapy team in South San Francisco is seeking a Scientist 3 to advance iPSC-derived T cell therapies. You will optimize differentiation protocols, investigate lineage decisions, and translate discoveries into improved cell-product quality and potency.

You will collaborate across multidisciplinary groups, contribute to strategy, and shape next-generation platforms essential for Genentech’s pipeline. A PhD with relevant experience completes the profile.

Qualifications

• PhD in Immunology, Stem Cell Biology, or related field with at least 3 years of relevant experience.
• Extensive hands-on experience differentiating iPSCs to T cell and/or other immune cell lineages.
• Strong cell and molecular biology background with a demonstrated ability to apply mechanistic approaches to investigate cell fate decisions.
• Proven track record of evaluating and optimizing the robustness, consistency, and reproducibility of stem cell differentiation platforms.
• Deep experience developing and applying phenotypic and functional assays to characterize T cell activity, fitness, and potency.

Responsibilities

• Develop, optimize, and implement robust iPSC-to-T cell differentiation protocols for diverse therapeutic programs.
• Investigate cellular and molecular mechanisms underlying T-cell lineage specification, differentiation efficiency, and maturation to drive process enhancements.
• Translate biological discoveries into improvements in cell-product quality, yield, phenotype, and function.
• Analyze complex, multidimensional datasets to draw conclusions and guide experimental strategies.
• Collaborate cross-functionally with research, translational, computational, process development, and external partner groups across gRED.
• Contribute to scientific and strategic planning for the Cell Therapy department and Genentech’s broader therapeutic pipeline.

Skills

iPSC differentiation

T cell biology

cell & molecular biology

data analysis

team collaboration

Education

PhD in Immunology or Stem Cell Biology

Tools

CRISPR/Cas9

DOE techniques

Job description

Genentech’s Cell Therapy team in South San Francisco is seeking a Scientist 3 to advance iPSC-derived T cell therapies. You will optimize differentiation protocols, investigate lineage decisions, and translate discoveries into improved cell-product quality and potency.

You will collaborate across multidisciplinary groups, contribute to strategy, and shape next-generation platforms essential for Genentech’s pipeline. A PhD with relevant experience completes the profile.