Scientist 3, Animal Genetic Technologies, Warming lab

F. Hoffmann-La Roche AG; South San Francisco (CA); On-site; USD 103,000 - 192,000; Full time

Benefits offered by this job

Relocation assistance

Job summary

Genentech, a member of the Roche group, is seeking a Scientist to join the Animal Genetic Technologies department in South San Francisco. You will develop and apply genome editing in vivo (CRISPR) in mouse models to identify modifiers of disease and validate new therapeutic targets.

The role focuses on combining genome editing with classic genetics, leveraging NGS and imaging to advance target discovery. A collaborative, fast-paced environment offers opportunities for technology development and

Qualifications

• Ph.D. degree in genetics and/or molecular biology with postdoctoral experience.
• Hands-on mouse model work with published track record.
• Strong molecular biology skills and publication record in model organism genetics, stem cells, genome editing, or synthetic biology.
• Hands-on experience with CRISPR, NGS-based technologies (RNA-seq, ChIP-seq, scRNA-Seq, Long-Read sequencing), microscopy, flow cytometry, and imaging.
• Exceptional organizational and communication skills; ability to work independently and in a fast-paced team.
• Interest in technology development and in vivo disease modeling with genome editing/engineering.
• Basic bioinformatics workflows and computational sequence analysis pipelines.
• Hands-on proficiency with viral vectors, AAV and lentiviral technologies.
• 3+ years post-PhD/biotech/pharma experience.
• Relocation benefits are available for this posting.

Responsibilities

• Develop and apply genome editing technologies (CRISPR) in vivo.
• Combine mouse genetics with genome editing to identify disease modifiers and validate targets.
• Collaborate with the Warming lab and other Genentech teams to advance target discovery and therapeutic concepts.
• Contribute to technology development and optimization within Animal Genetic Technologies.

Skills

CRISPR

NGS-based technologies

Microscopy

Flow cytometry

Imaging

AAV vectors

Lentiviral technologies

Mouse genetics

Molecular biology

Publication record

Team collaboration

Education

Ph.D. in genetics or molecular biology

Tools

RNA-seq

ChIP-seq

scRNA-Seq

Long-Read sequencing

Job description

The Opportunity

We have a great opportunity for a talented Scientist to join our Animal Genetic Technologies department and work in a South San Francisco-based lab that develops and uses state-of-the-art technology for genome manipulation in vivo. In a highly collaborative environment, the candidate will develop and use genome editing technology (including CRISPR) in combination with classic mouse genetics approaches to enable identification of novel modifiers of disease and validation of new targets for therapeutic intervention. The department of Animal Genetic Technologies broadly focuses on creation and genetic analysis of animal models to enable target discovery and validation. The Warming lab works closely with our animal model generation group as well as colleagues across therapeutic areas and across the Genentech research community.

Who You Are

• Ph.D. degree, or equivalent, in genetics and/or molecular biology, with relevant postdoctoral experience
• Hands-on experience, with a published track record, working with the mouse as a model system
• The candidate should have solid molecular biology skills and a strong publication record in a relevant field such as model organism genetics, stem cells, genome editing, and/or synthetic Biology
• Hands-on experience with relevant techniques, including CRISPR, NGS-based technologies (RNA-seq, ChIP-seq, scRNA-Seq, Long-Read sequencing, etc.), microscopy, flow cytometry and imaging
• Exceptional organizational and communication skills, the ability to work both independently and cooperatively in a fast-paced team environment
• A strong interest in technology development and a drive to explore the molecular basis of disease using in vivo models, genetics, and the latest genome editing/engineering technologies
• Basic hands-on experience with bioinformatics workflows and computational sequence analysis pipelines
• Hands-on proficiency with viral vector platforms, specifically Adeno-Associated Virus (AAV) and lentiviral technologies
• 3+ years of post-PhD or biotechnology/pharmaceutical industry experience
• Relocation benefits are available for this job posting
• The expected salary range for this position based on the primary location of South San Francisco, CA is $103,400 to $192,000
• Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law
• A discretionary annual bonus may be available based on individual and Company performance
• This position also qualifies for the benefits detailed at the link provided below

Benefits

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.

Who We Are

Genentech, a member of the Roche group and founder of the biotechnology industry, is dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases. To solve the world's most complex health challenges, we ask bigger questions that challenge our industry and the boundaries of science to transform society. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis. The next step is yours.

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.