Scientist 3, Lung Biology & Inflammation

F. Hoffmann-La Roche AG; South San Francisco (CA); Hybride; USD 103 000 - 192 000; Plein temps

Avantages offerts par ce poste

Discretionary annual bonus

Résumé du poste

Genentech, a member of the Roche group, is seeking a Scientist in Immunology with deep expertise in lung biology to uncover novel targets for respiratory diseases. You will lead projects exploring cellular mechanisms of lung injury, inflammation, and repair, and help advance programs into early clinical development.

The role requires a PhD with publications, hands-on molecular biology and organoid/ALI or organ-on-a-chip experience, and strong collaboration across departments.

Qualifications

• PhD in immunology, stem cell biology, molecular biology, biochemistry, or related field with strong publications.
• Deep understanding of lung biology, especially chronic respiratory diseases, tissue remodeling or host-microbe interactions.
• Hands-on expertise in molecular biology including transfections, gene expression profiling, genome editing, and RNA delivery.
• Experience with primary cell isolation from human or mouse tissues and multi-dimensional flow cytometry.
• Independent design/execution of complex experiments leading to first-author publications.

Responsabilités

• Lead research projects on cellular/molecular mechanisms of lung injury and repair.
• Advance research programs into early clinical development with robust proof-of-concept data.
• Utilize in vitro/in vivo models to evaluate novel molecules and delivery systems.
• Investigate MOA of therapies and contribute to target discovery.
• Collaborate across immunology, genetics, biomarkers, and early clinical development and present findings.

Connaissances

Lung biology expertise

Immunology experience

Flow cytometry

Organoid culture

Molecular biology techniques

RNA delivery technologies

In vitro/in vivo models

Formation

PhD in immunology or related field

Outils

Air–liquid interface (ALI) 3D cultures

Organs-on-a-chip

Description du poste

Why Genentech

We’re passionate about delivering on Our Promise to improve the lives of patients and create healthier communities for all. We foster a culture of inclusivity, integrity and creativity while boldly pursuing answers to the world’s most complex health challenges and transforming society.

The Opportunity

The Department of Immunology at Genentech is seeking a driven Scientist with deep expertise in lung biology and immunology to uncover novel therapeutic targets for respiratory diseases. In this role, you will lead research projects investigating the cellular and molecular mechanisms underlying the lung’s response to injury, chronic inflammation, and repair. Lead projects investigating cellular and molecular mechanisms underlying lung injury, chronic inflammation, and tissue repair. Advance novel research-stage programs into early clinical development by generating robust proof-of-concept data. Utilize state-of-the-art technologies, including in vitro and in vivo models, to evaluate novel molecules and targeted delivery systems. Dissect the pathogenesis of inflammatory lung diseases and identify the mechanism of action (MOA) of breakthrough therapies. Drive pipeline research while actively exploring new biologies and pathways for target discovery. Facilitate fruitful, open collaborations across immunology, human genetics, biomarker discovery, and early clinical development. Present research findings effectively at intra-and inter-departmental scientific meetings.

Who you are

PhD in immunology, stem cell biology, molecular biology, biochemistry, or a related field, with a demonstrated record of high-quality publications.
Deep understanding of lung biology, particularly in chronic respiratory diseases, tissue remodeling/regeneration, or host-microbe interactions.
Strong hands-on expertise in molecular biology, including cellular transfections, gene expression profiling, precision genome editing, and targeted RNA delivery technologies.
Hands-on experience with primary cell isolation from human or mouse tissues, in vitro immunological assays, and multi-dimensional flow cytometry.
Track record of independently designing, executing, troubleshooting, and interpreting complex experiments leading to first-author publication(s) in top-tier journals.
Preferred Proven experience with complex in vitro systems, including airway/alveolar organoids, air-liquid interface (ALI) 3D cultures, or organ-on-a-chip technologies.
Experience with targeted therapeutic delivery of nucleic acid modalities (e.g., mRNA, siRNA, ASOs) using viral or non-viral vectors.
Experience with computational data analysis, including scRNA-seq, spatial transcriptomics, or mining public/clinical datasets.

Location

This role is based in South San Francisco and offers a hybrid schedule working 3 day per week on campus. No relocation benefits are available for this posting.

Benefits

The expected salary range for this position based on the primary location of CA is $103,400.00 - 192,000.00 USD. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.

Who We Are

Genentech, a member of the Roche group and founder of the biotechnology industry, is dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases. To solve the world's most complex health challenges, we ask bigger questions that challenge our industry and the boundaries of science to transform society. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis. The next step is yours.