Scientist 3, Animal Genetic Technologies, Warming lab

Genentech; South San Francisco (CA); On-site; USD 103,000 - 192,000; Full time

Benefits offered by this job

Relocation benefits

Job summary

Genentech in South San Francisco invites a Scientist to join the Animal Genetic Technologies lab. You will develop and apply genome editing in vivo, combining CRISPR with mouse genetics to identify disease modifiers and validate new targets for therapy.

PhD in genetics or molecular biology plus postdoctoral experience, hands-on mouse work, strong molecular biology skills, and experience with CRISPR, NGS, and imaging are essential. Relocation benefits offered.

Qualifications

• PhD in genetics or molecular biology with relevant postdoctoral experience.
• Hands-on mouse work with a published track record.
• Solid molecular biology skills and publication record in model organism genetics.
• Experience with CRISPR, NGS (RNA-seq, ChIP-seq, scRNA-Seq), and imaging techniques.

Responsibilities

• Develop and apply genome editing in vivo using CRISPR in mouse models.
• Combine genome editing with mouse genetics to identify disease modifiers.
• Validate new therapeutic targets using genome engineering approaches.
• Collaborate across Genentech teams in a fast-paced research environment.

Skills

Mouse model system

Molecular biology

Genome editing

CRISPR

NGS sequencing

Team collaboration

Independent work

Education

PhD in genetics or molecular biology

Tools

AAV vectors

Lentiviral vectors

Flow cytometry

Imaging techniques

Job description

The Position

The Opportunity

We have a great opportunity for a talented Scientist to join our Animal Genetic Technologies department and work in a South San Francisco-based lab that develops and uses state-of-the-art technology for genome manipulation in vivo. In a highly collaborative environment, the candidate will develop and use genome editing technology (including CRISPR) in combination with classic mouse genetics approaches to enable identification of novel modifiers of disease and validation of new targets for therapeutic intervention. The department of Animal Genetic Technologies broadly focuses on creation and genetic analysis of animal models to enable target discovery and validation. The Warming lab works closely with our animal model generation group as well as colleagues across therapeutic areas and across the Genentech research community.

Who You Are

• Ph.D. degree, or equivalent, in genetics and/or molecular biology, with relevant postdoctoral experience

• Hands-on experience, with a published track record, working with the mouse as a model system

• The candidate should have solid molecular biology skills and a strong publication record in a relevant field such as model organism genetics, stem cells, genome editing, and/or synthetic Biology

• Hands-on experience with relevant techniques, including CRISPR, NGS-based technologies (RNA-seq, ChIP-seq, scRNA-Seq, Long-Read sequencing, etc.), microscopy, flow cytometry and imaging

• Exceptional organizational and communication skills, the ability to work both independently and cooperatively in a fast-paced team environment

• A strong interest in technology development and a drive to explore the molecular basis of disease using in vivo models, genetics, and the latest genome editing/engineering technologies

Preferred

• Basic hands-on experience with bioinformatics workflows and computational sequence analysis pipelines.

• Hands-on proficiency with viral vector platforms, specifically Adeno-Associated Virus (AAV) and lentiviral technologies.

• 3+ years of post-PhD or biotechnology/pharmaceutical industry experience.

Relocation benefits are available for this job posting.

The expected salary range for this position based on the primary location of South San Francisco, CA is $103,400 to $192,000. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.