Scientist 3 Translational Medicine (Cardiovascular and Metabolism)

F. Hoffmann-La Roche AG; South San Francisco (CA); Vor Ort; USD 100.000 - 186.000; Vollzeit

Zusammenfassung

Genentech’s Translational Medicine OMNI team is seeking a Scientist 3 to join on-site at the South San Francisco campus. You will work at the intersection of data science and wet lab, developing biomarkers and assays while analyzing -Omics data to inform CVM programs across drug development stages.

The ideal candidate holds a PhD in Biological Sciences with 0–6 years of wet lab and bioinformatics experience, including R/Python programming, and will contribute to high‑impact publications,

Qualifikationen

• A PhD in Biological Sciences and 0-6 years of experience in a post‑doc or industry setting with wet lab and bioinformatics experience demonstrated in high‑impact publications.
• Experience in human/clinical research or metabolism is a plus but not required.
• Experience with sample collection/processing and cellular/molecular lab techniques such as cell culture, tissue isolation, immunostaining, molecular biology, ELISA, western blot, sequencing, qRT-PCR, and/or transcriptomics is required.
• Programming experience (R or Python) to run differential expression pipelines and pathway enrichment analyses and to generate figures.
• Ability to develop hypotheses, design experiments, interpret and present results; strong written and oral communication; collaborative teamwork.

Aufgaben

• Establish and conduct experiments with disease‑relevant in‑vitro human cell models.
• Develop, qualify, and validate custom assays (e.g., ELISA, Simoa, NULISA) to support translational research and pipeline programs.
• Analyze -Omics datasets (proteomics, metabolomics, RNAseq) from clinical/preclinical samples to discover biomarkers and targets.
• Communicate findings through reports, publications, and presentations.
• Collaborate with gRED departments and external partners.

Kenntnisse

R or Python

Bioinformatics

Communication

Teamwork

Ausbildung

PhD in Biological Sciences

Tools

ELISA

Western blot

Genomic sequencing

qRT-PCR

Transcriptomics

Jobbeschreibung

We advance science so that we all have more time with the people we love. Genentech’s Translational Medicine OMNI (TM OMNI) Department supports the entire R&D portfolio of novel therapies in Ophthalmology, Metabolism, Neuroscience, and Immunology, (OMNI). We develop and implement biomarker strategies to study disease pathways, confirm a therapeutic’s mechanism of action, and improve clinical trial efficiency and success. Additionally, we conduct foundational clinical translational research to study the molecular and cellular pathways driving disease to generate novel target and biomarker approaches.

The Opportunity

We are seeking a talented and highly motivated Scientist 3 to join Genentech’s Translational Medicine (TM) team on-site at our South San Francisco campus. The candidate will collaborate with scientists across R&D to provide biomarker support for cardiovascular and metabolism (CVM) programs across different stages of drug development while also generating insights for the next generation of CVM drug targets. This role lies at the intersection of data science and the wet lab—analyzing and interpreting -Omics datasets while simultaneously developing assays and experiments to execute on data-driven insights. This is a hands‑on, high-impact position designed for a scientist who is eager to apply their scientific training to the complexities of drug development in an interdisciplinary, collaborative environment. As an integral member of our dynamic team, you will:

• Establish and conduct experiments with disease‑relevant in‑vitro human cell models.
• Develop, qualify, and validate custom assays (e.g., ELISA, Simoa, NULISA) to support disease‑oriented translational research & pipeline programs (goes beyond running commercial assay kits).
• Analyze -Omics datasets (e.g. proteomics, metabolomics, RNAseq) generated from clinical and preclinical samples to discover candidate biomarkers and targets.
• Clearly and concisely communicate findings internally and externally through written reports, publications, and presentations.
• Collaborate closely with other gRED departments and external partners.

Who You Are

The ideal candidate will have:

• A PhD in Biological Sciences and 0-6 years of experience in a post‑doc or industry setting with wet lab and bioinformatics experience demonstrated in high‑impact publications.
• Past experience with human/clinical research or a deep understanding of metabolism or metabolic diseases is a plus, but not required.
• Experience in, and deep technical understanding of, sample collection/processing and cellular/molecular lab techniques such as cell culture, primary cell isolation from tissues, immunostaining, molecular biology, ELISA, western blot, genomic sequencing, qRT-PCR, and/or transcriptomics is required.
• Sufficient programming experience (using R or Python) to run differential expression pipelines, perform pathway enrichment analysis, and generate compelling figures.
• Must demonstrate independence with ability to develop hypotheses, design experiments/studies, develop analysis plans, interpret and present results.
• Excellent oral and written presentation skills, creative problem-solving abilities, and a passion for drug discovery and development.
• Excellent teamwork, communication, time management, organization skills, and ability to work independently.

Locations

This is a primarily onsite position in South San Francisco. Relocation benefits are not available for this posting. The expected salary range for this position based on the primary location of California is $100,400 -186,400. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company’s policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.

Who We Are

Genentech, a member of the Roche group and founder of the biotechnology industry, is dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life‑threatening diseases. To solve the world’s most complex health challenges, we ask bigger questions that challenge our industry and the boundaries of science to transform society. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis. The next step is yours.

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company’s policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.