Scientist

Mindlance; South San Francisco (CA); Sur place; USD 140 000 - 190 000; Plein temps

Résumé du poste

Discovery Biotherapeutics and Genetic Medicine (BGM) at Mindlance is seeking a highly motivated scientist to join the Biotherapeutics group in South San Francisco. You will contribute to discovery and development of next generation biologics through production and interrogation of protein attributes.

The role involves MS analyses, LC/MS maintenance, and collaborating with CROs and internal teams to deliver production results and insights to therapeutic partners.

Qualifications

• BS/MS/PhD in chemistry, biochemistry, or related discipline with typical 7+ (BS), 5+ (MS), or 0+ (PhD) years of experience.
• Hands-on expertise with mass spectrometry platforms and MS workflows for protein characterization.
• Proficiency in data processing and bioinformatic/statistical workflows.
• Experience with LC/MS analyses for monoclonal antibodies, multispecifics, and protein therapeutics.
• Experience with coding/programming (Python, R) and developing automated data workflows.
• Experience with chromatography and purification systems (AKTA, Protein A/G, SEC, AEX) and analytical instruments (HPLC, UPLC, LC/MS).
• Strong verbal and written communication skills and ability to work in a fast-paced, multidisciplinary environment.

Responsabilités

• Conduct mass spectrometry analyses for comprehensive characterization of biologics, including intact and subunit approaches.
• Maintain LC/MS equipment and troubleshoot as needed.
• Design and execute production of biotherapeutic proteins to external CROs and relay results to therapeutic partners.
• Present findings and progress updates to colleagues and stakeholders.
• Collaborate with MS experts to assess and implement new bioanalytical technologies.
• Perform laboratory research and method development autonomously with high productivity.

Connaissances

Mass spectrometry

MS workflows

Data processing

Bioinformatics

Programming (Python/R)

Chromatography/purification

Communication

Formation

BS/MS/PhD in chemistry/biochemistry or related

Outils

Waters Xevo G2-XS QToF

MS software (UNIFI/Biosphere/Protein Metrics/Waters Connect)

AKTA systems

HPLC/UPLC

Description du poste

Discovery Biotherapeutics and Genetic Medicine (BGM) at company is seeking a highly motivated scientist to join the Biotherapeutics group at the company site in South San Francisco. This role offers a unique opportunity to contribute to various Discovery Research Therapeutic Areas (TAs) and projects by providing production and analytical characterization of biologics and biopharmaceutical products, such as monoclonal antibodies, multi-specifics, and other antibody-like formats. As part of our team, your work will drive the discovery and development of next generation biologics through production and interrogation of protein attributes.

Key responsibilities:

• Conduct mass spectrometry analyses for comprehensive characterization of biologics and biotherapeutics, including intact, reduced, and subunit approaches.
• Ensure the optimal functioning of LC/MS equipment through routine maintenance and effective troubleshooting.
• Design and execute production of biotherapeutic proteins to external CRO vendors, provide guidance on desired product quality attributes, then deliver the results of the production to our therapeutic partners.
• Contribute to team discussions, share valuable insights, and present experimental findings and progress updates to colleagues and stakeholders.
• Collaborates with MS experts across our Research & Development Division to assess and implement new bioanalytical technology.
• Independently and autonomously perform laboratory research and method development with minimal supervision, demonstrating high productivity and scientific initiative

Qualifications:

• BS, MS, or PhD in chemistry, biochemistry, or related discipline with typically 7+ (BS), 5+ (MS), or 0+ (PhD) years of relevant experience.
• Demonstrated hands-on expertise with various mass spectrometry platforms, including Waters Xevo G2-XS QToF, along with proficiency in MS workflows for protein characterization and the use of MS software for analyzing both routine and complex datasets.
• Proficiency in data processing and bioinformatic and statistical workflows (e.g., Protein Metrics, Biosphere, Waters Connect, UNIFI)
• Proven experience in the application of LC/MS analyses for interrogation of monoclonal antibodies, multispecific biologics, and protein therapeutics to provide sequence verification, post-translational modification, desired/expected chain pairing, and identity of DLP profile.
• Experience with coding/programming (e.g., Python, R, or relevant scripting languages) and in developing automated data workflows or solutions.
• Experience with chromatography and purification systems (protein A/G, AEX, SEC, mixed-mode with AKTA systems), and analytical instruments (Agilent HPLC, Waters UPLC and LC/MS, CE-SDS, SDS-PAGE) is a plus
• Goal-oriented team player with excellent verbal and written communication skills, a strong positive attitude, and the ability to thrive in a fast-paced, multidisciplinary environment.

EEO:

“Mindlance is an Equal Opportunity Employer and does not discriminate in employment on the basis of – Minority/Gender/Disability/Religion/LGBTQI/Age/Veterans.”