Biotherapeutics Mass Spec Scientist

Mindlance; South San Francisco (CA); On-site; USD 140,000 - 190,000; Full time

Job summary

Discovery Biotherapeutics and Genetic Medicine (BGM) at Mindlance is seeking a highly motivated scientist to join the Biotherapeutics group in South San Francisco. You will contribute to discovery and development of next generation biologics through production and interrogation of protein attributes.

The role involves MS analyses, LC/MS maintenance, and collaborating with CROs and internal teams to deliver production results and insights to therapeutic partners.

Qualifications

• BS/MS/PhD in chemistry, biochemistry, or related discipline with typical 7+ (BS), 5+ (MS), or 0+ (PhD) years of experience.
• Hands-on expertise with mass spectrometry platforms and MS workflows for protein characterization.
• Proficiency in data processing and bioinformatic/statistical workflows.
• Experience with LC/MS analyses for monoclonal antibodies, multispecifics, and protein therapeutics.
• Experience with coding/programming (Python, R) and developing automated data workflows.
• Experience with chromatography and purification systems (AKTA, Protein A/G, SEC, AEX) and analytical instruments (HPLC, UPLC, LC/MS).
• Strong verbal and written communication skills and ability to work in a fast-paced, multidisciplinary environment.

Responsibilities

• Conduct mass spectrometry analyses for comprehensive characterization of biologics, including intact and subunit approaches.
• Maintain LC/MS equipment and troubleshoot as needed.
• Design and execute production of biotherapeutic proteins to external CROs and relay results to therapeutic partners.
• Present findings and progress updates to colleagues and stakeholders.
• Collaborate with MS experts to assess and implement new bioanalytical technologies.
• Perform laboratory research and method development autonomously with high productivity.

Skills

Mass spectrometry

MS workflows

Data processing

Bioinformatics

Programming (Python/R)

Chromatography/purification

Communication

Education

BS/MS/PhD in chemistry/biochemistry or related

Tools

Waters Xevo G2-XS QToF

MS software (UNIFI/Biosphere/Protein Metrics/Waters Connect)

AKTA systems

HPLC/UPLC

Job description

Discovery Biotherapeutics and Genetic Medicine (BGM) at Mindlance is seeking a highly motivated scientist to join the Biotherapeutics group in South San Francisco. You will contribute to discovery and development of next generation biologics through production and interrogation of protein attributes.

The role involves MS analyses, LC/MS maintenance, and collaborating with CROs and internal teams to deliver production results and insights to therapeutic partners.