RNA Biologist (IVT and DNA Template) - Bench Lead

System One; Cambridge (MA); On-site; USD 122,951,000 - 166,345,000; Full time

Job summary

System One in Boston, MA is hiring a Molecular Biologist (RNA/IVT/DNA Template) for a contract‑to‑hire position onsite. The role focuses on bench‑level RNA science under the RNA Bio‑foundry Lead, driving analytical release strategies for batch release.

Compensation is $50.48 per hour with standard business hours and onsite work. The candidate will perform in‑vitro transcription, RNA purification, and DNA template preparation while maintaining strict custody of materials and ensuring high bench

Qualifications

• PhD or MS with five or more years in molecular biology, biochemistry, or a related discipline.
• At least five to eight years of hands‑on RNA work: in‑vitro transcription, capping, poly‑A tailing, RNA purification, and RNA quality analytics.
• Experience with LNP formulation and characterization, and with DNA template preparation.
• Excellent current bench skills and strict material handling in low bioburden/sterile operations.

Responsibilities

• Execute the wet‑laboratory science of the program at the bench, under the Head of RNA Bio‑foundry.
• Perform in‑vitro transcription across four modalities, including capping, poly‑A tailing, circularization chemistry, and guide RNA co‑production.
• Prepare DNA templates and conduct quality control from enzymatic cell‑free synthesis and rolling‑circle amplification processes.
• Conduct in‑process and release analytics: RNA integrity, capping efficiency, poly‑A length, dsRNA content, residual DNA, encapsulation efficiency, and particle characterization.
• Handle modality‑specific starting materials supplied by clinical and pharmaceutical partners, maintaining strict chain of custody.
• Document the primary data behind the de‑risking report and related datasets.

Skills

RNA work

In vitro transcription

RNA purification

LNP formulation

DNA template prep

Benchtop skills

Education

PhD or MS + 5+ years

Job description

System One in Boston, MA is hiring a Molecular Biologist (RNA/IVT/DNA Template) for a contract‑to‑hire position onsite. The role focuses on bench‑level RNA science under the RNA Bio‑foundry Lead, driving analytical release strategies for batch release.

Compensation is $50.48 per hour with standard business hours and onsite work. The candidate will perform in‑vitro transcription, RNA purification, and DNA template preparation while maintaining strict custody of materials and ensuring high bench