Molecular Biology Scientist (mRNA) - Design & Automation

Evolving Solution Services; Cambridge, Northern (MA, KY); Hybrid; USD 110,000 - 122,000; Full time

Job summary

Aera Therapeutics in Cambridge, MA is seeking a Scientist in Molecular Biology (mRNA) to design, build, and test mRNA, supporting platform advancement and discovery programs. You will collaborate with Therapeutics Discovery and Analytical Sciences to advance therapeutic mRNAs.

The role requires hands-on molecular biology skills, experience with RNA handling and automated liquid-handling platforms, and mammalian cell culture. Five days per week in the Cambridge office is expected.

Qualifications

• BS/MS/PhD in engineering or life sciences with relevant experience.
• Hands-on molecular biology skills: PCR, cloning, plasmid prep, gel/capillary electrophoresis.
• Experience with RNA handling and RNase-free workflows.
• Experience adapting assays on automated liquid-handling platforms.
• Mammalian cell culture and transfection experience.
• Knowledge of how mRNA sequence features affect protein expression.
• Commitment to Core Values: Respect, Integrity, Excellence, Impact.

Responsibilities

• Design and clone mRNA expression constructs, including transcription and purification.
• Transfect mammalian cells and quantify protein expression by Western blot, ELISA, or flow cytometry.
• Develop and automate in vitro assays to increase throughput.
• Integrate data across assays to understand sequence features driving performance.
• Serve as mRNA design representative on cross-functional teams.
• Maintain records in ELN and present data at team meetings.

Skills

Molecular biology

PCR

Cloning

Transfection

Flow cytometry

Western blot

ELISA

RNA handling

RNase-free workflow

Automation platforms

Mammalian cell culture

Education

BS (8+ years experience)

MS (6+ years experience)

PhD (2+ years experience)

Tools

Hamilton

Tecan

Opentrons

Job description

Aera Therapeutics in Cambridge, MA is seeking a Scientist in Molecular Biology (mRNA) to design, build, and test mRNA, supporting platform advancement and discovery programs. You will collaborate with Therapeutics Discovery and Analytical Sciences to advance therapeutic mRNAs.

The role requires hands-on molecular biology skills, experience with RNA handling and automated liquid-handling platforms, and mammalian cell culture. Five days per week in the Cambridge office is expected.