Research Associate

System One, Inc.; South San Francisco (CA); On-site; USD 41,000 - 48,000; Full time

Job summary

System One, Inc. is seeking a hands-on Research Associate to join the Discovery Chemistry Group in the Analytical Research department in South San Francisco, CA. The role supports small-molecule drug discovery by purifying small molecules, peptides, and macrocycles, primarily using preparative HPLC.

A strong background in purification and analytical chemistry is essential. The ideal candidate has hands-on chromatography experience (RP, NP, IEX, SPE), MS and NMR proficiency, and is comfortable

Qualifications

• BS degree in Chemistry or Biochemistry required; Master's considered.
• Strong knowledge of purification and chromatography techniques (RP, NP, IEX, SPE).
• Hands-on MS and NMR experience; LC-MS desirable.
• 2 years post-college experience preferred; academic lab acceptable.

Responsibilities

• Purify small molecules for drug discovery.
• Purify small molecules, peptides, macrocycles using preparative HPLC.
• Develop HPLC methods.
• Summarize, interpret, and present analytical data.
• Troubleshoot instruments and methods.
• Interact with chemists to support projects.
• Present findings at group meetings.
• Keep up to date with latest methods and technologies (HPLC, LC-MS, automation).
• Contribute to innovation and teamwork with state-of-the-art technology.

Skills

Purification

Analytical chemistry

Chromatography

HPLC

LC-MS

MS

NMR

Time management

Problem solving

Communication

Teamwork

Independence

Education

BS in Chemistry/Biochemistry

Master's degree considered

Tools

Preparative HPLC

LC-MS

NMR

Job description

Job Title: Research Associate
Location: South San Francisco, CA
Type: 12-month contract
Compensation: $30 - $35
Work Model: Onsite

Overview

We are seeking a hands-on Research Associate to join the Discovery Chemistry Group within the Analytical Research department. This individual will support small-molecule drug discovery through the purification of small molecules, short peptides, macrocycles, and other modalities, primarily utilizing preparative HPLC technology. The ideal candidate will have a strong background in purification and analytical chemistry, with practical experience in chromatography techniques and laboratory instrumentation.

Responsibilities

• Support the purification of small molecules for drug discovery.
• Be responsible for all aspects of purifying small molecules, short peptides, macrocycles, and other modalities, primarily using preparative HPLC technology.
• Develop HPLC methods.
• Summarize, interpret, and present analytical data and research findings.
• Troubleshoot instrument and method problems.
• Interact with chemists to support their projects.
• Present findings at group meetings.
• Keep up to date with the latest methods, technologies, and developments in the field.
• Contribute to innovation, teamwork, and creative problem-solving through the use of state-of-the-art technology, including HPLC, LC-MS, and various automation equipment.

Requirements

• BS degree in Chemistry, Biochemistry, or a related scientific discipline is required. Candidates with a Master's degree may also be considered.
• Strong theoretical knowledge of organic and analytical chemistry, with hands‑on experience in purification and chromatography techniques, including RP, NP, IEX, and SPE.
• Hands‑on experience with analytical techniques such as MS and NMR.
• Experience with preparative HPLC and LC-MS is highly desirable.
• Previous experience working in a high‑volume laboratory environment.
• Comfortable performing repetitive, hands‑on laboratory tasks.
• Ability to work in a fast‑paced environment while remaining highly organized, detail‑oriented, motivated, and capable of multitasking.
• Strong time management and problem‑solving skills.
• Ability to work collaboratively within a team as well as independently, with a strong sense of individual accountability.
• Excellent verbal and written communication and interpersonal skills.
• Ability to communicate technical findings and present analytical data to team members.
• Approximately 2 years of post‑college experience is preferred.
• Academic laboratory experience is acceptable.

System One, and its subsidiaries including Mountain Ltd., are leaders in delivering outsourced services and workforce solutions across North America. We help clients get work done more efficiently and economically, without compromising quality. System One not only serves as a valued partner for our clients, but we offer eligible employees health and welfare benefits coverage options including medical, dental, vision, spending accounts, life insurance, voluntary plans, as well as participation in a 401(k) plan.
System One is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, age, national origin, disability, family care or medical leave status, genetic information, veteran status, marital status, or any other characteristic protected by applicable federal, state, or local law.