Remote Senior Bioinformatics Scientist: Cancer Genomics

OMG Technology; Jersey City (NJ); Remote; USD 120,000 - 190,000; Full time

Job summary

OMG Technology seeks a Senior Bioinformatics Scientist to develop, optimize, and validate clinical-grade NGS algorithms for oncology diagnostics, including ctDNA and solid tumors. You will work on analytic validation, QC metrics, and regulatory documentation in a remote US setting.

The role requires strong cancer genomics expertise, proficiency in Python/R, and experience with variant calling tools and production pipelines. Collaboration with clinical and regulatory teams is essential.

Qualifications

• PhD or equivalent with extensive NGS experience in oncology diagnostics.
• Hands-on development and validation of NGS variant-calling algorithms.
• Experience with ctDNA, liquid biopsy, or oncology assay development.
• Proficiency in Python and/or R for data analysis.
• Familiarity with regulatory CLIA/CAP/FDA environments.

Responsibilities

• Develop and optimize NGS algorithms for SNVs, indels, CNVs, SVs, and RNA biomarkers.
• Design algorithms for ctDNA and oncology diagnostics.
• Apply statistical modeling and ML to improve assay performance.
• Plan and execute analytical validation studies (sensitivity, specificity, LoD).
• Develop and monitor QC metrics for clinical-grade pipelines.
• Analyze cancer genomics data using Python, R, and bioinformatics tools.
• Collaborate with software teams to deploy pipelines (Nextflow, Seqera, AWS HealthOmics).
• Prepare validation reports for regulatory submissions (CLIA, CAP, FDA).
• Lead PoC studies and work with assay development and regulatory teams.
• Troubleshoot and optimize clinical NGS analysis pipelines.

Skills

NGS data analysis

Cancer genomics

ctDNA / liquid biopsy

Python

R

Statistical modeling

Education

PhD in Bioinformatics/Computational Biology/Applied Statistics (4+ years)

Master's or Bachelor's with industry experience

Tools

GATK

Mutect2

VarDict

VEP

SnpEff

BWA

Samtools

BEDTools

VCF

BAM

Job description

OMG Technology seeks a Senior Bioinformatics Scientist to develop, optimize, and validate clinical-grade NGS algorithms for oncology diagnostics, including ctDNA and solid tumors. You will work on analytic validation, QC metrics, and regulatory documentation in a remote US setting.

The role requires strong cancer genomics expertise, proficiency in Python/R, and experience with variant calling tools and production pipelines. Collaboration with clinical and regulatory teams is essential.