Remote Principal Software Architect — Genomics Platform

Baylor Genetics; United States; Remote; USD 170,000 - 210,000; Full time

Job summary

Baylor Genetics in the United States is seeking a Senior Software Architect to lead the architecture, design, and development of complex software platforms in a remote-enabled IT environment. You will define engineering standards, drive long-term technical roadmaps, and mentor engineers across teams.

Collaborate with product, bioinformatics, and operations to deliver scalable, secure solutions while ensuring regulatory compliance.

Qualifications

• BS in Computer Science or related field required.
• 10+ years of professional software engineering experience.
• Expert-level proficiency with C# and .NET.
• Extensive experience architecting and building React + TypeScript applications.
• Deep expertise with relational databases (SQL Server, PostgreSQL, MySQL) and RESTful APIs.
• Strong background in software architecture, system design, and engineering best practices.
• Experience leading technical initiatives and mentoring engineers; solid DevOps/CI‑CD knowledge.

Responsibilities

• Lead the architecture, design, and development of complex software systems and platforms.
• Define and champion engineering standards, best practices, and long-term technical roadmaps.
• Collaborate with cross-functional teams to translate business needs into scalable, secure solutions.
• Conduct deep technical reviews and guide system design discussions across teams.
• Mentor engineers and foster a culture of technical excellence and continuous learning.
• Drive root-cause analysis and reliability improvements; ensure data integrity and security compliance.
• Evaluate emerging technologies and guide strategic adoption; partner with product, laboratory, and bioinformatics teams to optimize workflows.

Skills

C#

.NET

React

TypeScript

Agile

SDLC

HTML

Angular

Education

B.S. in Computer Science or related field

M.S. in Computer Science or related field

Tools

SQL Server

PostgreSQL

MySQL

RESTful APIs

DevOps

CI/CD

Cloud-native architectures

Job description

Baylor Genetics in the United States is seeking a Senior Software Architect to lead the architecture, design, and development of complex software platforms in a remote-enabled IT environment. You will define engineering standards, drive long-term technical roadmaps, and mentor engineers across teams.

Collaborate with product, bioinformatics, and operations to deliver scalable, secure solutions while ensuring regulatory compliance.