Remote Principal Scientist - NGS Diagnostics & Algorithms

NeoGenomics Laboratories, Inc.; United States; Remote; USD 190,000 - 240,000; Full time

Job summary

NeoGenomics Laboratories, Inc. is seeking a Principal Scientist Algorithm Lead – Clinical NGS Diagnostics to provide end-to-end scientific and technical leadership for clinical-grade NGS diagnostic algorithms, focusing on oncology and liquid biopsy applications.

The role covers algorithm design, analytical validation, design control, and regulatory readiness, with emphasis on improving sensitivity, robustness, and reproducibility across complex variant classes.

Qualifications

• PhD-level expertise required in computational genomics, statistics, or biomedicine.
• Strong coding and data analysis skills with emphasis on NGS.
• Proven ability to lead analytical validation.
• Experience with regulatory submissions (CLIA, CAP, FDA, NYDoH, MolDx).

Responsibilities

• Own end-to-end design and implementation of clinical NGS algorithms.
• Architect validation frameworks for accuracy, precision, and sensitivity.
• Define error models and performance metrics for low-VAF detection.
• Lead validation using truth sets, reference materials, and in silico methods.
• Serve as technical authority on algorithm changes and regulatory impact.
• Develop and optimize variant calling and signal extraction for DNA/RNA assays.

Skills

Python

R

Machine learning

Statistical modeling

Biomarker development

Education

PhD in Bioinformatics or related quantitative field

Job description

NeoGenomics Laboratories, Inc. is seeking a Principal Scientist Algorithm Lead – Clinical NGS Diagnostics to provide end-to-end scientific and technical leadership for clinical-grade NGS diagnostic algorithms, focusing on oncology and liquid biopsy applications.

The role covers algorithm design, analytical validation, design control, and regulatory readiness, with emphasis on improving sensitivity, robustness, and reproducibility across complex variant classes.