Remote Principal Scientist — Algorithm Lead, NGS Diagnostics

NeoGenomics; Northern (KY); Hybrid; USD 180,000 - 260,000; Full time

Job summary

NeoGenomics is seeking a Principal Scientist Algorithm Lead – Clinical NGS Diagnostics to provide end-to-end scientific leadership for clinical-grade algorithms with a focus on oncology and liquid biopsy. This is a remote position.

You will own algorithm design, analytical validation, design control, and regulatory readiness, driving improvements in sensitivity, robustness, and reproducibility across diverse variant classes while aligning with CLIA, CAP, FDA, NYDoH, CLSI, and MolDx standards.

Qualifications

• PhD in Bioinformatics, Computation Biology, CS, Statistics or related field.
• 8+ years developing algorithms for clinical NGS diagnostics, ideally oncology.
• Expert in SNV/indel, CNV, SV, fusion, and RNA analyses and QC metrics.
• Experience with regulatory submissions (CLIA, CAP, FDA, NYDoH, MolDx).

Responsibilities

• Own the full lifecycle of clinical NGS algorithms under design control and requirements definition.
• Architect automated analytical validation frameworks for accuracy, precision, and sensitivity.
• Define algorithm-level error models and acceptance criteria for low-VAF detection and artifact mitigation.
• Lead development of variant calling and signal extraction for DNA- and RNA-based assays.
• Translate QC performance into regulatory-ready analytical claims and validation reports.

Skills

Python

R

AI/ML

Statistical modeling

Education

PhD in Bioinformatics or related field

Job description

NeoGenomics is seeking a Principal Scientist Algorithm Lead – Clinical NGS Diagnostics to provide end-to-end scientific leadership for clinical-grade algorithms with a focus on oncology and liquid biopsy. This is a remote position.

You will own algorithm design, analytical validation, design control, and regulatory readiness, driving improvements in sensitivity, robustness, and reproducibility across diverse variant classes while aligning with CLIA, CAP, FDA, NYDoH, CLSI, and MolDx standards.