Remote Clinical Bioanalytical Chemist (LC-MS/MS)

National Institutes of Health; Maryland; Remote; USD 102,000 - 133,000; Full time

Job summary

The National Institutes of Health (NIH) in Maryland seeks an analytical chemist within the Clinical Pharmacology Program. The role supports clinical pharmacology and translational drug development by developing and applying quantitative bioanalytical methods to measure drugs and metabolites in biological samples.

Responsibilities include LC-MS/MS method development and validation, instrument maintenance, and data interpretation to support PK/PD objectives.

Qualifications

• Experience in quantitative bioanalysis and method development
• Familiarity with chromatographic techniques and validation
• Ability to interpret PK/PD data and communicate results

Responsibilities

• Develop, validate, transfer, and apply LC-MS/MS methods for quantitative analysis of drugs and metabolites in biological samples.
• Operate, maintain, and troubleshoot HPLC/UHPLC and tandem MS systems; evaluate sensitivity, selectivity, and matrix effects.
• Prepare calibrators, internal standards, blanks, and QC samples; document method validation and investigations.
• Acquire, process, review, and report quantitative data; support pharmacokinetic data interpretation for clinical studies.

Skills

Analytical chemistry

Bioanalytical methods

Pharmacokinetics

Education

Bachelor's degree in a relevant field

Tools

LC-MS/MS

HPLC/UHPLC

Job description

The National Institutes of Health (NIH) in Maryland seeks an analytical chemist within the Clinical Pharmacology Program. The role supports clinical pharmacology and translational drug development by developing and applying quantitative bioanalytical methods to measure drugs and metabolites in biological samples.

Responsibilities include LC-MS/MS method development and validation, instrument maintenance, and data interpretation to support PK/PD objectives.