Remote Biology Research Scientist — Target Validation

YO AI Labs; Palo Alto (CA); Remote; USD 83,000 - 165,000; Part time

Job summary

YO AI Labs is seeking a Biology Research Scientist contractor to validate protein target assignments against primary sources and UniProt records. You will review papers and patents, identify errors, and propose corrected UniProt accessions with concise, evidence-based conclusions.

This role requires bench-level expertise in pharmacology, biochemistry, molecular biology, or chemical biology, and you will work remotely for 10–20 hours per week with an initial 1–2 month duration and potential

Qualifications

• BA/BS with 5+ years industry research experience; MS with 2+ years; or PhD with relevant drug discovery exposure.
• Background in pharmacology, biochemistry, molecular biology, or chemical biology in biotech/pharma/CRO environments.
• Hands-on experience with assays such as SPR, TR-FRET, radioligand binding, kinase assays, or GPCR functional assays.
• Experience interpreting IC50, Ki, and Kd data.
• Active bench-based researcher in a lab role.
• Working knowledge of UniProt or related workflows (SAR, HTS, target validation, biochemical profiling, or IND-enabling studies).
• Experience with ChEMBL, BindingDB, or PubChem; selectivity profiling or counterscreening; understanding agonist/antagonist vs activator/inhibitor distinctions.

Responsibilities

• Review primary research papers and patents to verify protein target assignments.
• Compare target assignments against UniProt and identify discrepancies.
• Classify target assignment errors using a structured taxonomy.
• Propose accurate UniProt accessions where assignments are incorrect.
• Document clear, evidence-grounded reasoning for each determination.
• Apply pharmacology, biochemistry, molecular biology, or chemical biology expertise to evaluate target relationships.

Skills

Protein Target Identification

UniProt

Primary Literature Review

Protein Biochemistry

Molecular Biology

Pharmacology

Binding Assays

Data Interpretation

Evidence-Based Reasoning

Technical Documentation

Education

BA/BS + 5 years

MS + 2 years

PhD with industry experience

Tools

SPR

TR-FRET

Radioligand Binding

Kinase Assays

GPCR Functional Assays

UniProt workflows

Job description

YO AI Labs is seeking a Biology Research Scientist contractor to validate protein target assignments against primary sources and UniProt records. You will review papers and patents, identify errors, and propose corrected UniProt accessions with concise, evidence-based conclusions.

This role requires bench-level expertise in pharmacology, biochemistry, molecular biology, or chemical biology, and you will work remotely for 10–20 hours per week with an initial 1–2 month duration and potential