R&D FP&A Strategic Leader — Forecasting & Growth

Dyne Therapeutics, Inc.; Waltham (MA); On-site; USD 233,000 - 285,000; Full time

Job summary

Dyne Therapeutics, Inc. is seeking a Senior Director of Financial Planning & Analysis — R&D to lead strategic planning, forecasting, and reporting for the Research and Development organization.

This role partners with Finance leadership and cross-functional teams to translate scientific priorities into disciplined financial plans and actionable insights. Based in Waltham, MA, the role drives long-range planning, model development, and executive-ready analyses.

Qualifications

• Bachelor’s degree in Finance, Accounting, Economics, Business, or a related field.
• Advanced degree, CPA, CFA, or MBA preferred.
• 15+ years of progressive finance, FP&A, corporate finance, strategic finance, or related experience, preferably in biotechnology, pharmaceuticals, life sciences, or another high-growth R&D-driven environment.
• 8+ years of experience leading people, teams, major workstreams, or a finance function, directly or through cross-functional leadership.
• Strong understanding of biotechnology financial drivers, including R&D investment planning, clinical development spend, ROI analysis, program timelines, vendor commitments, headcount planning, operating expense management, and cash runway considerations.
• Experience building and maintaining live clinical trial forecasting models, with the ability to identify key cost assumptions and drivers and support scenario planning across clinical programs.
• Demonstrated ability to lead annual planning, forecasting, long-range planning, management reporting, scenario analysis, and executive-level financial presentations.
• Experience partnering with R&D, Clinical Development, CMC, Technical Operations, Commercial, G&A, or other functional leaders to align operating plans with corporate strategy and financial targets.
• Strong working knowledge of US GAAP, SOX requirements, accrual processes, budget-to-actual reporting, financial controls, and close-related FP&A responsibilities.
• Deep financial modeling, analytical, and problem-solving skills, with the ability to synthesize complex data into clear insights, recommendations, and trade-off decisions.
• Demonstrated ability to influence senior stakeholders, reconcile multiple perspectives, manage interdependencies, and drive outcomes in a matrixed environment without relying solely on formal authority.
• Proven ability to build scalable processes, reporting infrastructure, financial models, dashboards, and planning tools that improve transparency, accountability, and decision-making.
• Strong executive presence and communication skills, including the ability to prepare and deliver concise, accurate, and compelling materials for senior leaders and governance forums.

Responsibilities

• Lead annual budgeting, quarterly forecasting, long-range planning, and scenario modeling processes across R&D functions: Research, Clinical Development, Regulatory and Portfolio Strategy & Operations and the cross-functional program leadership team.
• Partner with the VP, FP&A to develop, manage, and continuously improve Dyne’s enterprise planning calendar, planning assumptions, financial models, templates, reporting packages, and governance processes.
• Serve as a trusted finance business partner to R&D functions: Research, Clinical Development, Regulatory and Portfolio Strategy & Operations and the cross-functional program leadership team, providing financial insights that support strategic decision-making, portfolio prioritization, operating discipline, and resource allocation.
• Translate program timelines, clinical development plans, headcount plans, vendor commitments, and functional priorities into clear financial forecasts and actionable recommendations.
• Partner closely with the program leadership team and Clinical Operations to develop and manage a live clinical trial forecasting model that clearly identifies key assumptions and drivers, enabling robust scenario planning and informed investment decisions.
• Lead program- and function-level budget reviews, challenging assumptions, identifying risks and opportunities, and ensuring alignment between financial plans, corporate goals, program milestones, and functional priorities.
• Develop and maintain robust financial models, dashboards, and reporting tools that provide visibility into spend, cash runway, operating performance, clinical and program costs, headcount, and key business drivers.
• Prepare and present executive-ready financial analyses, variance explanations, forecast updates, and recommendations for Finance leadership, the CFO, senior leadership, and other governance forums as needed.
• Lead monthly and quarterly actuals reporting, variance analysis, accrual support, and close-related FP&A activities in partnership with Accounting, Procurement, and functional budget owners.
• Partner with Accounting to ensure appropriate expense recognition, accrual accuracy, budget-to-actual transparency, and alignment with US GAAP, SOX requirements, and company policies.
• Support strategic analyses related to capital planning, cash runway, business development opportunities, program investment decisions, launch readiness, and other enterprise priorities.
• Identify, implement, and scale process improvements that increase forecast accuracy, planning discipline, reporting consistency, transparency, and efficiency across the FP&A function.
• Support implementation, optimization, and adoption of financial planning systems and enterprise tools, including planning applications, reporting dashboards, and related integrations.
• Foster accountability and financial ownership across the organization by enabling clear communication, practical guidance, and consistent operating rhythms with functional leaders and budget owners.
• Build, coach, and develop FP&A talent as the function evolves, creating a collaborative, inclusive, high-performing team culture grounded in Dyne’s values.
• Model Dyne’s core values by leading with purpose, accountability, transparency, collaboration, sound judgment, and a commitment to continuous improvement.
• Perform ad-hoc financial analysis and support special projects as required

Skills

FP&A leadership

Forecasting

Financial modeling

Executive communications

Cross-functional partnering

Education

Bachelor’s degree

Advanced degree preferred

Tools

Excel

PowerPoint

ERP systems

Planning software

Job description

Dyne Therapeutics, Inc. is seeking a Senior Director of Financial Planning & Analysis — R&D to lead strategic planning, forecasting, and reporting for the Research and Development organization.

This role partners with Finance leadership and cross-functional teams to translate scientific priorities into disciplined financial plans and actionable insights. Based in Waltham, MA, the role drives long-range planning, model development, and executive-ready analyses.