Protein Chemistry & Bioconjugation RA I/II – Cambridge

Ring Therapeutics; Cambridge (MA); On-site; USD 43,000 - 62,000; Full time

Job summary

Ring Therapeutics, a Cambridge-based biotech company, seeks a Research Associate I/II for the Protein Chemistry & Bioconjugation team. You will support production, modification, and characterization of antibodies and proteins to underpin therapeutic programs.

The role emphasizes hands-on bench work, data quality, and collaboration across protein engineering and analytical groups. Prior ADC exposure is desirable; independence and rigorous documentation are essential.

Qualifications

• BS or MS in Biochemistry, Bioengineering, Chemistry, or a related field.
• BS: 1–4 years hands-on laboratory experience in biotech/pharma/academic setting.
• MS: 0–2 years hands-on laboratory experience in biotech/pharma/academic setting.
• Proficiency in standard protein workflows and measurements.
• Hands-on experience with at least one bioconjugation approach (e.g., NHS ester, maleimide, click chemistry).

Responsibilities

• Execute common bioconjugation reactions.
• Prepare and characterize antibody- and protein-conjugated constructs (e.g., fluorophore labeling, payload attachment).
• Perform post-conjugation purification techniques including desalting columns and TFF.
• Perform standard protein analytics and concentration measurements.
• Prepare formulation buffers and working reagents.
• Conduct buffer exchange and protein concentration.
• Maintain accurate experimental records and SOPs in an ELN.
• Ensure proper inventory management of reagents, consumables, and protein stocks.
• Present data clearly and provide actionable recommendations to project teams.
• Collaborate cross-functionally with targeting, protein engineering, analytical, and translational teams.

Skills

Protein workflows

Bioconjugation chemistry

Analytical techniques

ELN documentation

Team collaboration

Education

BS in Biochemistry/Bioengineering/Chemistry

MS in Biochemistry/Bioengineering/Chemistry

Tools

UV-Vis spectroscopy

BCA/Bradford

SDS-PAGE

DLS

Dialysis

IMAC

SEC

Ion exchange chromatography

TFF

Job description

Ring Therapeutics, a Cambridge-based biotech company, seeks a Research Associate I/II for the Protein Chemistry & Bioconjugation team. You will support production, modification, and characterization of antibodies and proteins to underpin therapeutic programs.

The role emphasizes hands-on bench work, data quality, and collaboration across protein engineering and analytical groups. Prior ADC exposure is desirable; independence and rigorous documentation are essential.