Process Development Senior Scientist

Avecia Pharma; Milford (MA); On-site; USD 104,000 - 127,000; Full time

Job summary

Avecia Pharma is seeking a Process Development Senior Scientist to plan and conduct development of oligonucleotide processes, including synthesis, purification, ultrafiltration and lyophilization. You will lead scale-up, process optimization and characterization activities while reporting progress to Process Development leadership.

The role involves preparing samples for analysis, maintaining rigorous documentation, and ensuring compliance with EH&S policies, while providing technical direction

Qualifications

• Bachelor’s degree and 8+ years related experience in science-related discipline, Master’s degree and 5+ years related experience in science-related discipline, or Ph.D. degree and 0+ years related experience in science-related discipline.
• General knowledge of chemical laboratory procedures and equipment.

Responsibilities

• Carries out development/improvement of oligonucleotide processes and assists in solving manufacturing process issues.
• Prepares API samples for customer use following best procedures to produce required material with acceptable quality.
• Participates in PD project team activities ensuring project requirements and timelines are met.
• Prepares sections of technical development protocols, reports, and campaign summaries documenting experiments and conclusions.
• Maintains laboratory documentation using standard scientific record keeping practices
• Adheres to EH&S policies and procedures.
• Performs and monitors assigned group responsibilities to maintain an efficient laboratory
• Develops up-to-date knowledge of oligonucleotide chemistry principles, theories, and processes.

Skills

Process development

Scale-up

Documentation

Oligonucleotide chemistry

Laboratory practices

Education

Bachelor's degree in science

Master's degree in science

PhD in science

Tools

Laboratory equipment

Job description

The Process Development Senior Scientist plans and conducts development of processes and methods for the synthesis, purification, ultrafiltration, and lyophilization of new and existing oligonucleotide products. Prepares and tests samples for analysis. Conducts and helps lead product scale-up, process optimization, and process characterization activities. Reports status of assigned activities to Process Development leadership. Normally receives general instruction on routine work and on new assignments. Provides technical direction and detailed instruction to laboratory personnel for routine work and on new assignments.

Key Responsibilities:

• Carries out laboratory work to develop/improve oligonucleotide processes and to assist in the solution of manufacturing process issues.
• Conducts laboratory preparations of API samples for customer use utilizing best available procedures and practices to produce requested amounts of material with acceptable quality attributes.
• Participates in PD project team activities ensuring that project requirements and timelines are met. Updates PD Management, project teams, and customers as appropriate on project activities
• Prepares appropriate sections of technical development protocols, technical development reports, and campaign summary reports to properly document laboratory experimentation and conclusions.
• Maintains and reviews laboratory documentation using standard scientific record keeping practices
• Adheres to all company and departmental environmental health and safety policies and procedures.
• Performs and monitors assigned group responsibilities to maintain an efficient operating laboratory
• Maintains an appropriate level of training on company and departmental procedures as determined by Avecia and Process Development. Prepares draft departmental operational procedures and work instructions.
• Develops and maintains up-to-date knowledge of oligonucleotide chemistry principles, theories, and processes

Required Skills/Abilities:

• Bachelor’s degree and 8+ years related experience in science-related discipline, Master’s degree and 5+ years related experience in science-related discipline, or Ph. D. degree and 0+ years related experience in science-related discipline.
• General knowledge of chemical laboratory procedures and equipment.

The annualized salary for this position is $103,800.00 - $127,000.00.