Principal Software Architect, Genomics & Healthcare

Baylor Genetics; Houston, Northern (TX, KY); Hybrid; USD 160,000 - 230,000; Full time

Job summary

Baylor Genetics in Houston is seeking a Principal Software Engineer onsite to lead architecture across the software ecosystem, driving design, scalability, and secure systems supporting genetic testing workflows.

You will mentor engineers, partner with scientists and product leaders, and ensure regulatory compliance while delivering robust solutions that improve patient care. This role demands deep technical expertise, leadership, and a track record in large-scale systems.

Qualifications

• BS in Computer Science or related field.
• 10+ years of professional software engineering experience.
• Expert in C# and .NET (e.g., .NET Core / .NET 6+).
• Experience architecting React + TypeScript applications.
• Deep expertise with relational databases (MS SQL Server, PostgreSQL, MySQL).
• Proven experience designing RESTful APIs and distributed systems.
• Strong background in software architecture and engineering best practices.
• Leadership and mentoring experience across teams.
• Strong DevOps, CI/CD, cloud-native knowledge.

Responsibilities

• Lead architecture, design, and development of complex software systems and platforms.
• Define and champion engineering standards, best practices, and long-term roadmaps.
• Collaborate with cross-functional teams to translate business needs into scalable solutions.
• Conduct deep technical reviews and ensure architectural consistency across teams.
• Mentor and coach engineers to foster technical excellence and learning.
• Drive root-cause analysis for reliability and data integrity.
• Evaluate emerging technologies and guide strategic adoption.
• Partner with product, lab, and bioinformatics teams to optimize workflows.

Skills

C# / .NET

React

TypeScript

SQL Server

REST APIs

Distributed systems

DevOps

Leadership

Education

B.S. in Computer Science

M.S. preferred

Tools

Azure

CI/CD

Docker

Job description

Baylor Genetics in Houston is seeking a Principal Software Engineer onsite to lead architecture across the software ecosystem, driving design, scalability, and secure systems supporting genetic testing workflows.

You will mentor engineers, partner with scientists and product leaders, and ensure regulatory compliance while delivering robust solutions that improve patient care. This role demands deep technical expertise, leadership, and a track record in large-scale systems.