Principal Software Engineer

Baylor Genetics; Houston, Northern (TX, KY); On-site; USD 160,000 - 230,000; Full time

Job summary

Baylor Genetics in Houston is seeking a Principal Software Engineer onsite to lead architecture across the software ecosystem, driving design, scalability, and secure systems supporting genetic testing workflows.

You will mentor engineers, partner with scientists and product leaders, and ensure regulatory compliance while delivering robust solutions that improve patient care. This role demands deep technical expertise, leadership, and a track record in large-scale systems.

Qualifications

• BS in Computer Science or related field.
• 10+ years of professional software engineering experience.
• Expert in C# and .NET (e.g., .NET Core / .NET 6+).
• Experience architecting React + TypeScript applications.
• Deep expertise with relational databases (MS SQL Server, PostgreSQL, MySQL).
• Proven experience designing RESTful APIs and distributed systems.
• Strong background in software architecture and engineering best practices.
• Leadership and mentoring experience across teams.
• Strong DevOps, CI/CD, cloud-native knowledge.

Responsibilities

• Lead architecture, design, and development of complex software systems and platforms.
• Define and champion engineering standards, best practices, and long-term roadmaps.
• Collaborate with cross-functional teams to translate business needs into scalable solutions.
• Conduct deep technical reviews and ensure architectural consistency across teams.
• Mentor and coach engineers to foster technical excellence and learning.
• Drive root-cause analysis for reliability and data integrity.
• Evaluate emerging technologies and guide strategic adoption.
• Partner with product, lab, and bioinformatics teams to optimize workflows.

Skills

C# / .NET

React

TypeScript

SQL Server

REST APIs

Distributed systems

DevOps

Leadership

Education

B.S. in Computer Science

M.S. preferred

Tools

Azure

CI/CD

Docker

Job description

Job Category: Information Technology (IT)

Requisition Number: PRINC002466

• Posted : August 13, 2026
• Full-Time
• On-site

Locations

Showing 1 location

Headquarters
Baylor Genetics
Houston, TX 77021, USA

Description

As we continue to grow and expand our services, we are seeking an accomplished Principal Software Engineer to work ONSITE to serve as a technical leader and architect across our software ecosystem. This role is responsible for driving the design, scalability, and evolution of mission‑critical systems that support genetic testing workflows, clinical reporting, and data‑driven insights. The ideal candidate combines deep technical expertise with strong leadership, systems thinking, and the ability to influence engineering direction across teams. This position will collaborate closely with geneticists, bioinformaticians, laboratory professionals, and product leaders to deliver robust, secure, and innovative software solutions that directly impact patient care.

KEY RESPONSIBILITIES

• Lead the architecture, design, and development of complex software systems and platforms
• Define and champion engineering standards, best practices, and long‑term technical roadmaps
• Collaborate with cross‑functional teams to translate business needs into scalable, secure, and maintainable solutions
• Conduct deep technical reviews, guide system design discussions, and ensure architectural consistency across teams
• Mentor and coach engineers, fostering a culture of technical excellence and continuous learning
• Drive root‑cause analysis and resolution of complex technical issues, ensuring system reliability and data integrity
• Evaluate emerging technologies and guide strategic adoption where appropriate
• Partner with product, laboratory, and bioinformatics teams to optimize workflows and enhance operational efficiency
• Ensure compliance with security, privacy, and regulatory requirements across all software systems
• Contribute to innovation initiatives that advance Baylor Genetics’ digital capabilities and competitive advantage
• Perform other duties as assigned to support team and organizational objectives.
• Comply with all company policies, procedures, and applicable regulatory requirements.

QUALIFICATIONS

Required

• B.S. in Computer Science or related field required
• 10+ years of professional software engineering experience, including significant experience in large‑scale or complex systems
• Expert‑level proficiency with C# and .NET (e.g., .NET Core / .NET 6+)
• Extensive experience architecting and building React + TypeScript applications
• Deep expertise with relational databases such as MS SQL Server, PostgreSQL, or MySQL, including schema design, performance tuning, and data modeling
• Proven experience designing, implementing, and governing RESTful APIs and distributed systems
• Strong background in software architecture, system design, and engineering best practices
• Demonstrated experience leading technical initiatives, mentoring engineers, and influencing cross‑functional decision‑making
• Strong understanding of DevOps principles, CI/CD pipelines, and cloud‑native architectures
• Excellent analytical and problem‑solving skills with the ability to navigate ambiguity and complexity
• Equivalent combination of education and experience may be considered.

Preferred

• M.S. or higher preferred in Computer Science or related field
• Experience in healthcare, clinical diagnostics, genomics, or NGS environments
• Familiarity with laboratory workflows, LIMS systems, or clinical reporting platforms
• Experience working in regulated environments (CLIA, CAP, HIPAA)
• Background in designing secure, compliant, and audit‑ready systems
• Experience with high‑performance or data‑intensive applications, including optimization and scalability strategies

COMPETENCIES

• A strategic technical leader who can define long‑term architectural direction
• Strong ownership mindset with the ability to drive initiatives from concept to production
• Exceptional communication skills, capable of translating complex technical concepts for diverse audiences
• A collaborative partner who elevates team performance and mentors engineers at all levels
• Sound judgment balancing innovation, speed, quality, and regulatory requirements
• Passion for building systems that directly support clinical decision‑making and patient outcomes

PHYSICAL DEMANDS AND WORK ENVIRONMENT

• Physical demands for the job (e.g., Must be able to lift 25 lbs, standing for prolonged periods of time, etc.)
• Work environment required for the job duties (e.g., Exposure to laboratory chemicals, etc.)
• Special conditions (e.g. lab/clinical requirements if applicable)

EEO Statement

Baylor Genetics is proud to be an equal opportunity employer committed to fostering an inclusive and diverse workplace. We welcome and encourage applicants from all backgrounds to apply. We do not discriminate on the basis of race, color, religion, national origin, sex, sexual orientation, gender identity, age, veteran status, disability, genetic information, pregnancy, childbirth, or any other status protected by applicable federal, state, or local law. If you need an accommodation during the application process, please contact our Human Resources team.

Equal Opportunity Employer
This employer is required to notify all applicants of their rights pursuant to federal employment laws. For further information, please review the Know Your Rights notice from the Department of Labor.