Principal Scientist – Inflammation Discovery (AI + Lab, Hybrid)

BioSpace; South San Francisco (CA); On-site; USD 170,000 - 210,000; Full time

Benefits offered by this job

Total Rewards Plan

Group medical, dental and vision

Retirement and savings plan

Discretionary annual bonus program

Stock-based long-term incentives

Generous time-off plans

Flexible work models

Job summary

Amgen is seeking a Principal Scientist to join its Integrated Computational and Experimental Inflammation Discovery area in South San Francisco. You will combine wet-lab biology with AI/ML-driven computational methods to accelerate discovery and development of therapies for inflammation.

You will leverage deep expertise across experimental biology and computational research to generate data-driven mechanistic insights, support target identification, and inform decision-making across projects and

Qualifications

• PhD, PharmD, or MD with relevant experience in Inflammation/Immunology research.
• Master's degree with 5+ years of industry experience in Inflammation/Immunology.
• Bachelor's degree with 7 years of industry experience in Inflammation/Immunology.
• Demonstrated ability to work in collaborative, matrixed environments.
• Experience applying AI/ML to biological discovery.

Responsibilities

• Apply computational, AI-driven approaches to generate mechanistic insights and guide experiments.
• Design, execute, and interpret studies to investigate disease mechanisms.
• Generate high-quality data to support target identification and progression of inflammation programs.
• Integrate experimental findings with literature, human genetics, and clinical observations.
• Participate in scientific discussions, target reviews, and portfolio evaluations.

Skills

AI/ML in biology

Wet-lab biology

Data integration

Cross-functional collaboration

Education

PhD

PharmD

MD with industry experience

Masters in related field

Bachelors in related field

Job description

Amgen is seeking a Principal Scientist to join its Integrated Computational and Experimental Inflammation Discovery area in South San Francisco. You will combine wet-lab biology with AI/ML-driven computational methods to accelerate discovery and development of therapies for inflammation.

You will leverage deep expertise across experimental biology and computational research to generate data-driven mechanistic insights, support target identification, and inform decision-making across projects and