Senior Principal Scientist: AI-Driven Inflammation & Computation

Amgen Inc.; South San Francisco (CA); On-site; USD 171,000 - 231,000; Full time

Job summary

Amgen Inc. seeks a Senior Principal Scientist Integrated Technology, Computation & Experimental Biology to lead discovery programs across inflammation research.

You will shape strategy, integrate experimental biology with computational science, and drive AI-enabled approaches to accelerate therapeutic discovery. You will collaborate across cross-functional teams, mentor scientists, and translate complex biology into scalable, data-driven experiments, ultimately advancing pipeline programs and

Qualifications

• Doctorate or professional degree with 3+ years in computational biology and multi-omics data integration.
• Alternatively, Master’s with 6 years of computational biology and multi-omics data integration.

Responsibilities

• Provide scientific leadership for discovery programs and cross-functional teams.
• Define therapeutic hypotheses and translate into computational analyses and experiments.
• Leverage AI-enabled approaches to synthesize data and identify mechanisms.
• Guide program strategy, milestones, and risk assessment.
• Identify emerging technologies to advance inflammation research.

Skills

computational biology

multi-omics data integration

leadership

cross-functional collaboration

experimental biology

inflammation biology

Education

PhD

PharmD

MD

Master's degree

Bachelor's degree

Tools

AI-enabled tools

agentic workflows

machine learning

data analysis software

Job description

Amgen Inc. seeks a Senior Principal Scientist Integrated Technology, Computation & Experimental Biology to lead discovery programs across inflammation research.

You will shape strategy, integrate experimental biology with computational science, and drive AI-enabled approaches to accelerate therapeutic discovery. You will collaborate across cross-functional teams, mentor scientists, and translate complex biology into scalable, data-driven experiments, ultimately advancing pipeline programs and