Principal Scientist (Director), Translational Medicine - Cardiovascular

Scorpion Therapeutics; Pennsylvania; Hybrid; USD 180,000 - 260,000; Full time

Benefits offered by this job

Hybrid work model

Travel opportunities

Job summary

Scorpion Therapeutics is seeking a Principal Scientist (Clinical Director) to lead early clinical development of cardiovascular therapeutics, focusing on Phase 1/2 studies. You will drive clinical strategy for novel compounds from Preclinical Candidate to Proof-of-Concept, and shape biomarker integration across programs.

The role requires MD or MD/PhD with a strong translational track record and 10+ years in clinical medicine or early drug development.

Qualifications

• MD or MD/PhD with proven clinical research record.
• Biomedical research background.
• Strong communication skills and 10+ years in clinical medicine/translational research/early drug development.

Responsibilities

• Design and execute clinical strategies for novel compounds from Preclinical Candidate approval through Proof-of-Concept.
• Develop biomarker strategies and validate clinical platforms.
• Support target identification/validation.
• Collaborate across discovery, translational, and late-stage clinical teams.
• Provide clinical pharmacology input for worldwide regulatory filings.
• Communicate study results to governance teams.

Skills

Clinical leadership

Clinical pharmacology

Translational research

Early drug development

Communication skills

Cross-functional collaboration

Education

MD or MD/PhD

Job description

Role: Principal Scientist (Clinical Director) leading early clinical development of cardiovascular therapeutics, focusing on Phase 1 and 2 studies.

Responsibilities: design and execute clinical strategies for novel compounds from Preclinical Candidate approval through Proof-of-Concept, develop biomarker strategies, validate clinical platforms, and support target identification/validation. Collaborate broadly across discovery, translational, and late-stage clinical teams; provide clinical pharmacology input for worldwide regulatory filings; communicate study results to governance teams.

Requirements: MD or MD/PhD with proven clinical research record, biomedical research background, and strong communication skills; 10+ years in clinical medicine, translational research, or early drug development.

Preferred: clinical subspecialty in cardiology, nephrology, or pulmonary; clinical board certification; translational research experience.

High-Value: cardiovascular disease focus, early clinical development, biomarker integration, cross-functional collaboration, hybrid work model, ~10% travel.