Principal Scientist, AI-Driven Biologics Discovery

Johnson & Johnson Co.; San Diego (CA); On-site; USD 117,000 - 201,000; Full time

Job summary

Johnson & Johnson seeks a Principal Scientist, AI-Native Discovery (Large Molecules) to join our In Silico Discovery team. You will help shape AI-native biologics discovery by integrating AI, predictive modeling, and computational design into Therapeutic Discovery programs.

This role is located in Spring House, PA; Cambridge, MA; or San Diego, CA with travel as needed. No remote option. You will lead computational design efforts and guide experimental strategy with AI-driven insights.

Qualifications

• PhD in a relevant scientific or technical discipline with 3+ years in drug discovery.
• Experience contributing to cross-functional discovery teams.
• Expertise in AI, machine learning, computational biology, or antibody design.

Responsibilities

• Lead AI-enabled design and predictive modeling to inform discovery decisions.
• Collaborate with cross-functional biologics teams to shape program strategy.
• Develop AI-native workflows linking hypothesis, design, and experiments.

Skills

PhD required

AI/ML in discovery

Cross-functional collaboration

Biologics discovery

Computational design

Education

PhD in relevant field

Job description

Johnson & Johnson seeks a Principal Scientist, AI-Native Discovery (Large Molecules) to join our In Silico Discovery team. You will help shape AI-native biologics discovery by integrating AI, predictive modeling, and computational design into Therapeutic Discovery programs.

This role is located in Spring House, PA; Cambridge, MA; or San Diego, CA with travel as needed. No remote option. You will lead computational design efforts and guide experimental strategy with AI-driven insights.