Principal Engineer, Microsoft 365 and Copilot Platforms

Vertex Pharmaceuticals Inc (US); Boston (MA); Hybrid; USD 144,000 - 216,000; Full time

Benefits offered by this job

Medical, dental and vision benefits

Generous paid time off

Educational assistance programs

Commuting subsidy

Matching charitable donations

401(k)

Job summary

Vertex Pharmaceuticals Inc is seeking a Principal Engineer for Microsoft 365 and Copilot Platforms to lead and deliver secure, governed enterprise AI capabilities. The role blends hands-on work (about 60%) with technical leadership (40%), spanning Teams, SharePoint Online, OneDrive, Exchange, and AI governance.

You will drive design, delivery, and cross-functional collaboration across a regulated enterprise.

Qualifications

• Bachelor's degree or equivalent in Information Systems, Computer Science, Engineering, Business, or related discipline.
• Extensive experience delivering and governing enterprise Microsoft 365 Modern Work capabilities.
• Experience implementing Microsoft Copilot, Copilot Studio, enterprise agents, AI governance, or related AI productivity capabilities is strongly preferred.
• Experience working in a regulated enterprise environment with security, privacy, legal, compliance, identity, and operational teams is strongly preferred.

Responsibilities

• Own Modern Work and AI initiatives, including design, change control, and delivery.
• Lead escalations, incident management, and root-cause analysis.
• Advance Copilot and AI enablement across SharePoint, Copilot Studio, Power Automate and Power Apps.
• Act as the technical authority, challenge solution designs, and coordinate with stakeholders.
• Create and maintain environment documentation, SOPs, and KB articles.

Skills

Microsoft 365

Copilot

Teams

SharePoint Online

OneDrive

Exchange

AI governance

GitHub Copilot

Automation

Education

Bachelor's degree

Tools

Copilot Studio

Power Automate

Power Apps

GitHub Copilot

Entra ID

Job description

Job Description General Summary

The Principal Engineer, Microsoft 365 and Copilot Platforms serves as the execution-focused technical lead for Microsoft 365 Modern Work and enterprise AI capabilities. This role translates business demand into secure, governed, supportable outcomes. The ideal candidate provides technical leadership across Microsoft Teams, SharePoint Online, OneDrive, Exchange with deep specialization in Microsoft Copilot, GitHub Copilot, Copilot Studio, agents, and AI governance. The role balances approximately 60% hands on work with 40% technical leadership.

Key Duties and Responsibilities

• Own Technical Delivery: Lead Modern Work and AI initiatives, technical design, change control, implementation, working with our operations team.
• Lead business escalations, Critical incident management, root cause analysis and troubleshooting.
• Lead Microsoft Copilot and AI Enablement: Copilot - SharePoint agents, Cowork Copilot Studio - Power Automate, Power Apps GitHub & GitHub Copilot Drive automation and continuous improvement across platforms.
• Act as the technical authority for the team by challenging solution design, coordinating working sessions, and engaging with stakeholders across the business and driving solutions.
• Create and maintain environment documentations, SOP, KB articles for supported technologies.

Knowledge and Skills

Broad Microsoft 365 Expertise: Principal- or Lead-level knowledge across Microsoft Teams, SharePoint Online, OneDrive, Exchange, Microsoft 365 governance, and related Entra ID, security, and compliance dependencies. Deep practical knowledge of Microsoft Copilot, Copilot Studio, Power Automate and Power Apps, agents, AI governance, and enterprise adoption controls - Agent 365. Demonstrated ability to convert broad objectives and business requirements into secure technical designs and completed delivery outcomes. Ability to balance business enablement, user experience and operational sustainability in a regulated enterprise environment. Experience leading complex technical escalations and coordinating execution across internal teams, control functions, vendors, and managed service providers. Excellent written and verbal communication skills, including the ability to explain technical decisions, risks, and recommendations to technical and non-technical audiences. Strong analytical and problem-solving skills, with comfort operating through ambiguity, incomplete information, shifting priorities, and multiple dependencies.

Education and Experience

• Bachelor's degree (or equivalent degree) in Information Systems, Computer Science, Engineering, Business, or a related discipline, or equivalent professional experience.
• Extensive experience delivering and governing enterprise Microsoft 365 Modern Work capabilities, including ownership of complex technical delivery, operational escalations, and cross-functional implementation.
• Experience implementing Microsoft Copilot, Copilot Studio, enterprise agents, AI governance, or related AI productivity capabilities is strongly preferred.
• Experience working in a regulated enterprise environment and partnering with security, privacy, legal, compliance, identity, and operational teams is strongly preferred.

Pay Range

Pay Range: $144,000 - $216,000

Disclosure Statement

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

Benefits and Perks

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations.

• medical, dental and vision benefits
• generous paid time off (including a week-long company shutdown in the Summer and the Winter)
• educational assistance programs including student loan repayment
• generous commuting subsidy
• matching charitable donations
• 401(k)
• so much more

Flex Designation

Flex Designation: Hybrid-Eligible Or On-Site Eligible

Flex Eligibility Status

In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law.

Vertex is an E-Verify Employer in the United States.

Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [e-mail]

Help Us Achieve Our Mission Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases and conditions.

The company has approved therapies for cystic fibrosis, sickle cell disease, transfusion-dependent beta thalassemia, acute pain and acromegaly, and it continues to advance clinical and research programs in these areas.

Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including IgA nephropathy, neuropathic pain, APOL1-mediated kidney disease, primary membranous nephropathy, congenital adrenal hyperplasia, ACTH-dependent Cushing's syndrome, autosomal dominant polycystic kidney disease, type 1 diabetes, generalized myasthenia gravis, and myotonic dystrophy type 1.

Vertex was founded in 1989 and has its global headquarters in Boston, with international headquarters in London.

Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East.

Vertex is consistently recognized as one of the industry's top places to work, including 17 consecutive years on Science magazine's Top Employers list and one of Fortune's 100 Best Companies to Work For.

For company updates and to learn more about Vertex's history of innovation, visit www.vrtx.com or follow us on LinkedIn, Facebook, Instagram, YouTube, and X

We believe our culture is one of Vertex's greatest strengths and a key enabler of our ability to deliver transformative medicines for patients who need them.

Rooted in innovation, purpose and collaboration, our culture empowers people to take smart risks, challenge conventional thinking and do their best work.

The diversity of our people is central to that culture. By bringing together individuals with different backgrounds, experiences and perspectives, we foster an environment where new ideas thrive, better decisions are made and breakthrough innovation is possible.

We are committed to creating a workplace where everyone feels valued, included and connected to our shared mission, because we know that our unique culture and the collective strength of our people are what set Vertex apart.