Senior Principal, Source to Pay Technology

Vertex Pharmaceuticals Inc (US); United States; Hybrid; USD 178,000 - 266,000; Full time

Benefits offered by this job

Annual bonus

Equity awards

Medical, dental, vision

Paid time off

Commuting subsidy

Student loan repayment

401(k) matching

Job summary

Vertex is seeking a Senior Principal, Source to Pay Technology to lead AI-powered solutions and orchestration, implementing and maintaining S2P platforms. You will partner with global stakeholders to define needs and design solutions across regulatory and privacy frameworks.

The role requires expertise in AI/ML, integrations, and established program management, with a hybrid work model in the United States and a strong focus on compliant, scalable delivery.

Qualifications

• Bachelor’s degree in technology or equivalent.
• 8+ years of relevant experience in life sciences or related systems.
• Experience with implementing AI/ML in Source-to-Pay or similar domains.

Responsibilities

• Advise stakeholders on Source-to-Pay tech and AI solutions to enable business goals.
• Collaborate with global stakeholders to define needs and future-state requirements.
• Implement AI capabilities in Source-to-Pay while ensuring compliance and privacy.
• Document integrations and design testing strategies; work with offshore teams and vendors.
• Manage relationships with strategic software vendors and service providers.

Skills

Source-to-Pay technologies

AI/ML capabilities

Requirements gathering

Integrations and documentation

Stakeholder collaboration

Program and project management

Agile / DevOps practices

Strong communication

Education

Bachelor’s degree in technology or equivalent

Tools

Icertis

ProcessUnity

Docusign

Coupa

Job description

Job Description General Summary

The Senior Principal, Source to Pay Technology will provide technical expertise, delivery, and support for Source-to-Pay AI-powered technologies. This role will focus on the implementation and subsequent maintenance of Source to Pay Orchestration solutions and AI capabilities. This role will partner with business leadership to identify and prioritize opportunities to improve business processes with innovative technology and data, gathering and refining requirements, determining options for solution design, delivering enhancements, supporting integrations, and contributing to technology projects and initiatives.

Key Duties and Responsibilities

• Serve as a trusted advisor for business stakeholders on Source to Pay technology and AI solutions to support and enable the business goals and objectives
• Collaborate with business stakeholders to understand their current and future state strategy, needs, and requirements from a global perspective
• Implement AI capabilities in the Source to Pay space while meeting compliance, legal, and ethical standards, including data privacy and regulatory requirements
• Proactively offer innovative technologies and solution ideas, and potential business process improvements in pursuit of driving efficiencies and meeting business needs
• Facilitate workshops and discussions to collect and document user stories / requirements
• Develop and document functional and technical aspects for integrations with upstream and downstream platforms
• Design, perform and document system configurations within in-scope platforms and applications
• Contribute to the creation and documentation of testing strategies and execution plans
• Work with offshore team members and peers for platform support and technical development of enhancements and projects
• Manage relationships with strategic software vendors and managed service providers (as needed)
• Work closely with Privacy, DTE Compliance, and Internal Audit to ensure compliance with all appropriate regulations, data integrity policies, and Vertex’s system lifecycle and change management processes

Knowledge and Skills

• Experience with Source to Pay technologies (e.g., Contract Lifecycle Management platform (Icertis), Third-Party Risk Management platform (ProcessUnity), Electronic Signature platform (Docusign), Procure-to-Pay platform (Coupa), and Source to Pay Orchestration tools)
• In-depth knowledge and hands-on experience implementing AI/ML technologies
• Demonstrated ability to translate business challenges into AI-driven solutions with measurable outcomes
• Functional and technical expertise with application configurations, integrations, and documentation
• Demonstrated ability to understand, analyze, and document complex business processes, translate business needs and functional requirements into technical or process-driven solutions
• Self-directed individual who is able to work independently and collaboratively in a matrixed team environment
• Experience in program and project management, demand management, resource management and system lifecycle management
• Results-oriented individual with a proven track record of on-time project delivery for large, complex projects with global stakeholders
• Exceptional analytical, quantitative, problem-solving, and prioritization skills
• In-depth experience in design, development, and deployment of technology solutions using agile software development practices and dev/ops model
• Very strong written and verbal communication skills and ability to present in a clear and concise manner to various technical and non-technical audiences
• Demonstrated ability to solve complex business problems by collaborating across organizational boundaries

Education and Experience

• Bachelor’s degree in technology discipline or equivalent
• 8+ years of work experience with relevant business systems in the Life Sciences industry, or the equivalent combination of education and experience
• Experience working with implementation partners as well as managed services providers and/or offshore teams

Preferred experience with ZipHQ #LI-HYBRID

At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.

Pay Range

$177,600 - $266,400

Disclosure Statement

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation

Hybrid-Eligible Or On-Site Eligible

Flex Eligibility Status

In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

Company Information

Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [e-mail] Help Us Achieve Our Mission Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases and conditions. The company has approved therapies for cystic fibrosis, sickle cell disease, transfusion-dependent beta thalassemia, acute pain and acromegaly, and it continues to advance clinical and research programs in these areas. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including IgA nephropathy, neuropathic pain, APOL1-mediated kidney disease, primary membranous nephropathy, congenital adrenal hyperplasia, ACTH-dependent Cushing’s syndrome, autosomal dominant polycystic kidney disease, type 1 diabetes, generalized myasthenia gravis, and myotonic dystrophy type 1. Vertex was founded in 1989 and has its global headquarters in Boston, with international headquarters in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 16 consecutive years on Science magazine’s Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex’s history of innovation, visit www.vrtx.com or follow us on LinkedIn, Facebook, Instagram, YouTube, and X We believe our culture is one of Vertex’s greatest strengths and a key enabler of our ability to deliver transformative medicines for patients who need them. Rooted in innovation, purpose and collaboration, our culture empowers people to take smart risks, challenge conventional thinking and do their best work. The diversity of our people is central to that culture. By bringing together individuals with different backgrounds, experiences and perspectives, we foster an environment where new ideas thrive, better decisions are made and breakthrough innovation is possible. We are committed to creating a workplace where everyone feels valued, included and connected to our shared mission, because we know that our unique culture and the collective strength of our people are what set Vertex apart.