Computational Immunology Scientist: Multiomics Target Discovery

AbbVie Inc.; Cambridge (MA); On-site; USD 120,000 - 180,000; Full time

Job summary

AbbVie Inc. in Cambridge, MA is seeking a Computational Immunology Scientist to develop computational approaches for disease biology and drug responses using multiomics data.

You will integrate scRNA-seq, scATAC-seq, TCR/BCR, bulk RNA-seq, and proteomics to characterize cell states and identify therapeutic opportunities. The role involves collaboration across teams, contributing to publications and regulatory filings, and working in a multidisciplinary environment to advance AbbVie's immunology

Qualifications

• BS or MS degree in computational biology, bioinformatics, genomics, biostatistics, computer science, or related quantitative field.
• Typically 5-7+ years (BS) or 2-5+ years (MS) of relevant experience.
• Hands-on scRNA-seq analysis experience or scATAC-seq/TCR/BCR analysis desired.
• Proficiency in Python and/or R; Linux computing environment experience.
• Familiarity with tools like Scanpy, AnnData, Cell Ranger, scvi-tools, DESeq2, GSEA, WGCNA.

Responsibilities

• Analyze scRNA-seq, scATAC-seq, and TCR/BCR data with QC, integration, clustering, and annotations.
• Integrate cohorts with reference atlases, perform differential expression and pathway analyses.
• Analyze multiomics data to prioritize targets and biomarkers; document workflows; leverage cloud/HPC.
• Collaborate with internal/external scientists; communicate findings and contribute to publications.

Skills

Python

R

Linux

Scanpy

AnnData

Cell Ranger

scvi-tools

DESeq2

GSEA

WGCNA

AWS

SLURM

Education

BS or MS in computational biology or related field

Tools

Python

R

Linux

Job description

AbbVie Inc. in Cambridge, MA is seeking a Computational Immunology Scientist to develop computational approaches for disease biology and drug responses using multiomics data.

You will integrate scRNA-seq, scATAC-seq, TCR/BCR, bulk RNA-seq, and proteomics to characterize cell states and identify therapeutic opportunities. The role involves collaboration across teams, contributing to publications and regulatory filings, and working in a multidisciplinary environment to advance AbbVie's immunology